Erythroderma: A clinico-etiological study of 92 cases
Keywords:
Erythroderma, frequency, psoriasis, dermatitis, ichthyosisAbstract
Objective To determine frequency of various causes associated with erythroderma. Methods This cross-sectional study was conducted in Dermatology Departments, JPMC and PNS Shifa Hospital. All the patients of erythroderma presenting fulfilling inclusion and exclusion criteria were enrolled. Complete history was taken and physical examination was done. Skin biopsy was performed and cause was established. Date were entered and analyzed in SPSS version 16. Results A total of 92 cases fulfilling the inclusion/exclusion criteria were enrolled. 66 (72%) were males whereas 26 (28%) were females. Mean age was 43.48±7.25 years. 50 (54.6%) patients were between 21-40 years and 42 (45.4%) were between 41-60 years of age. Regarding causes of erythroderma, psoriasis was the most frequent cause of erythroderma seen in 38 (41.3%) patients followed by dermatitis in 16 (17.4%), ichthyosis in 6 (6.5%) and scabies in 4 (4.3%) patients. Conclusion Psoriasis is the commonest disease associated with erythroderma followed by dermatitis and ichthyosis. Awareness of these frequent causes can help us to develop an efficient strategy for diagnosis and appropriate management of the disease.References
REFERENCES:
Mistry N, Gupta A, Alavi A, Sibbald RG. A review of the diagnosis and
management of erythroderma (generalized red skin). Adv Skin Wound Care.2015 May;28(5):228-36; quiz 237-8.
CEDEF.. [Item 314--Erythroderma]. Ann Dermatol Venereol. 2012 Oct;139(11 Suppl):A219-22.
Tan GF, Kong YL, Tan AS, Tey HL. Causes and features of erythroderma. Ann Acad Med Singapore. 2014 Aug;43(8):391-4.
Banerjee S, Ghosh S, Mandal RK. A Study of Correlation Between Clinical and Histopathological Findings of Erythroderma in North Bengal Population. Indian J Dermatol. 2015 Nov-Dec;60(6):549-55.
Patrizi A, Venturi M. Erythroderma. In European Handbook of Dermatological Treatments 2015 (pp. 287-302). Springer Berlin Heidelberg.
Pal S, Haroon TS. Erythroderma: a clinicoetiologic study of 90 cases. Int J Dermatol 1998;37:104-7.
Hafeez J, Shaikh ZI, Mashhood AA, Frequency of various etiological factors associated with erythroderma, JPAD, 2010;20:70-74.
Prakash BV, Sirisha NL, Satyanarayana VV, Sridevi L, Ramachandra BV. Aetiopathological and clinical study of erythroderma. J Indian Med Assoc. 2009 Feb;107(2):100,102-3.
Khaled A, Sellami A, Fazaa B, Kharfi M, Zeglaoui F, Kamoun MR. Acquired
erythroderma in adults: a clinical and prognostic study.J Eur Acad DermatolVenereol. 2010 Jul;24(7):781-8.
Li J, Zheng HY. Erythroderma: a clinical and prognostic study. Dermatology 2012; 225:154.
César A, Cruz M, Mota A, Azevedo F. Erythroderma. A clinical and etiological study of 103 patients. J Dermatol Case Rep. 2016 Mar 31;10(1):1-9.
Khaled A, Sellami A, Fazaa B, Kharfi M, Zeglaoui F, Kamoun MR. Acquired
erythroderma in adults: a clinical and prognostic study. J Eur Acad Dermatol Venereol. 2010 Jul;24(7):781-8.
Hulmani M, NandaKishore B, Bhat MR, et al. Clinico-etiological study of 30 erythroderma cases from tertiary center in South India. Indian Dermatology Online Journal. 2014;5(1):25-29.
Talat H, ZehraU, Wahid Z. Frequency of common etiologies of erythroderma in patients visiting a tertiary care hospital in Karachi. J Pak Assoc Derm. 2016;26 (1):48-52.
Kulkarni S, Shah H, Patel B, Bhuptani N. Crusted Scabies: Presenting as erythroderma in a human immunodeficiency virus-seropositive patient. Indian J Sex Transm Dis. 2016 Jan-Jun;37(1):72-4.
Torres-Camacho P, Tirado-Sanchez A, Ponce-Olivera RM. A study of erythroderma: Clues from eosinophilia and elevated lactate dehydrogenase levels. Indian J Dermatol Venereol Leprol 2008;74:499-500.
Nagler AR, Samimi S, Schaffer A, Vittorio CC, Kim EJ, Rook AH .Peripheral blood findings in erythrodermic patients: importance for the differential diagnosis of Sézary syndrome. J Am Acad Dermatol. 2012 Mar;66(3):503-8. Epub 2011 Oct 17.
Okoduwa C, Lambert WC, Schwartz RA, et al. Erythroderma: review of a potentially life-threatening dermatosis. Indian Journal of Dermatology. 2009;54(1):1-6. doi:10.4103/0019-5154.48976.
Çetinözman F, Jansen PM, Willemze R. Expression of programmed death-1 in skin biopsies of benign inflammatory vs. lymphomatous erythroderma.Br J Dermatol. 2014;171(3):499.
Zattra E, Belloni Fortina A, Peserico A, Alaibac M. Erythroderma in the era of biological therapies. Eur J Dermatol. 2012 Mar-Apr;22(2):167-71.