Efficacy of intralesional vitamin D3 in cutaneous warts
DOI:
https://doi.org/10.66344/jpad.33.4.2023.2268Keywords:
Plantar warts, Cutaneous warts, Intralesional treatment, Vitamin D3, EfficacyAbstract
Objective: The objective of this study was to determine the efficacy of intralesional vitamin D3 in cutaneous warts Study Design: Descriptive Case Series Study Place and Duration of Study: Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi from August 2018 to February 2019. Methodology: The study comprised 226 patients with palmoplantar warts of various sizes and duration. After injecting lignocaine with 0.2 ml (20 mg/ml), about 0.5 mL of vitamin D3 solution (200,000 IU, 15 mg/mL) was administered to the base of the warts. At 2-week intervals, up to 5 warts might be injected every session until they disappeared, which could take up to 4 treatments. Following the final injection, patients were monitored for 6 months to look for any recurrence. Results: The study was completed by 226 patients. The average number of injections needed to obtain a complete resolution was 2.93+0.60. Complete response was observed in 185 (81.9%) patients. Conclusion: Cutaneous warts can be treated effectively, affordably, and safely with intralesional vitamin D3. Keywords: Plantar Warts, Cutaneous Warts, Intralesional Treatment, Vitamin D3, Efficacy.References
Sterling JC, Handfield-Jones, Hudson PM. British association of dermatologists. Guidelines for the management of cutaneous warts. Br J Dermatol. 2001;144:4-11.
Gibss S, Harvey I, Sterling J, Stark R. Local treatments for cutaneous warts: systematic review. BMJ. 2002;325:461.
Savant SS, Gore D. Electro surgery. In: Savant SS, Shah RA, Gore D, editors. Textbook and Atlas of Dermatosurgery and Cosmetology. Mumbai: ASCAD; 2005. P. 305-14.
Bourke JF, Berth-Jones J, Hutchinson PE. Cryotherapy of common viral warts at intervals of 1, 2 and 3 weeks. Br J Dermatol. 1995;132:433-6.
Tan OT, Hurwitz RM, Stafford TJ. Pulsed dye laser treatment of recalcitrant verrucae: a preliminary report. Lasers Surg Med. 1993;13:127-37
Nofal A, Nofal E. Intralesional immunotherapy of common warts: Successful treatment with mumps, measles and rubella vaccine. J Eur Acad Dermatol Venereol. 2010;24:1166- 70.
Shaheen MA, Saleem SA, Fouad DA, El-Fatah AA. Intralesional tuberculin (PPD) versus measles, mumps, rubella (MMR) vaccine in treatment of multiple warts: a comparative clinical and immunological study. Dermatol Ther. 2015;28:194-200.
Garg S, Baveja S. Intralesional immunotherapy for difficult to treat warts with Mycobacterium w vaccine. J Cutan Aesthet Surg. 2014;7:203-8.
Majid I, Imran S. Immunotherapy with intralesional Candida albicans antigen in resistant or recurrent warts: a study. Indian J Dermatol. 2013;58:360-5.
Bhutto AM, Shah AH, Ahuja DK, Solangi AH, Shah SA. Pattern of sexually transmitted infections in males in interior Sindh. A 10 year study. J Ayub Med Coll Abbott. 2011;23(3):110-4.
Rind T, Oiso N, Kawada A. Successful treatment of anogenital wart with a topical Vitamin D(3) derivative in an infant. Case Rep Dermatol. 2010;2:46-9.
Imagawa I, Suzuki H. successful treatment of refractory warts with topical Vitamin D3 derivative (maxacalcitol, 1alpha, 25-dihydroxy-22-oxacalcitriol) in 17 patients. J Dermatol. 2007;34:264-6.
AlGhamdi K, Kumar A, Moussa N. The role of vitamin D in melanogenesis with an emphasis on vitiligo. Indian J Dermatol Venereol Leprol. 2013;79:750-8.
Aktas H, Ergin C, Demir B, Ekiz O. Intralesional vitamin D injection may be an effective treatment option for warts. J Cutan Med Surg. 2016;20:118-22.
Leung L. Treating common warts - options and evidence. Aust Fam Physician 2010;39:933-7.
Loo SKF, Tang WYM. Warts (non-genital). BMJ Clin Evid 2009;2009:1710.
Bhutto AM, Shah AH, Ahuja DK, Solangi AH, Shah SA. Pattern of sexually transmitted infections in males in interior Sindh: a 10-year-study. J Ayub Med Coll Abbott 2011;23:110-4.
Namburi URS, Omprakash, Babu G. A review on management of warts in Ayurveda. Ayu 2011;32:100-2.
Hannuksela M. Treatment of common warts. Duodecim 2012;128:1797-802.
Aktas H, Ergin C, Demir B, Ekiz O. Intralesional Vitamin D Injection May Be an Effective Treatment Option for Warts. J Cutan Med Surg 2016;20:118-22.
Dall'oglio F, D'Amico V, Nasca MR, Micali G. Treatment of cutaneous warts: an evidence-based review. Am J Clin Dermatol 2012;13:73-96.
Das S, Chowdhury J, Patra S, Ghoshal L, Banerjee S. Auto-wart inoculation: An easy and effective treatment of multiple, recalcitrant and genital warts. J Pak Assoc Dermatol 2017;26:229-34.
Gupta R. Plantar warts treated with topical adapalene. Indian J Dermatol 2011;56:513-4.
Gharib IEl, Aly DG, Emam HM, Khater OH. Evaluation of acitretin in the treatment of multiple recalcitrant common warts: a pilot study. Pigment Dis 2015;2:183-7.
Miller J, Gallo RL. Vitamin D and innate immunity. Dermatol Ther 2010;23:13-22.
Uyar B, Sacar H. Comparison of cryotherapy session intervals in the treatment of external genital warts. Dermatologica Sinica 2014;32:154-6.
Lal NR, Sil A, Gayen T, Bandyopadhyay D, Das NK. Safety and effectiveness of autoinoculation therapy in cutaneous warts: a double--blind, randomized, placebo-controlled study. Indian J Dermatol Venereol Leprol 2014;80:515-20.
Syed TA, Hadi SM, Qureshi ZA, Ali SM, Kwah MS. Treatment of external genital warts in men with imiquimod 2% in cream. A placebo-controlled, double-blind study. J Infect 2000;41:148-51
Downloads
Published
How to Cite
Issue
Section
License
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.
