Demographic, Clinical and Histopathological Spectrum of Leprosy ; A Study of 30 Pakistani Patients
DOI:
https://doi.org/10.66344/jpad.v27i4.935Keywords:
Leprosy, clinical features, histopathology, bacillary index, granulomatous disorder, nerve enlargement, MALCAbstract
Methods We selected 30 new and previously untreated cases of leprosy that presented at Marie Adelaide Leprosy Center, Karachi, from January 01, 2016 to July 31, 2016 and were diagnosed by a senior leprologist. Information on demographic, clinical and histopathological features of each patient was then collected from the medical records.
Results Mean age of presentation was 36.47±17.57 years with age range of 07-69 years. Male to female ratio was 3.2:1. History of a household contact was positive in 11 (37%) cases. Ulnar nerve was the most common nerve enlarged (83%) and borderline lepromatous leprosy was the most common type of disease.
Conclusion Leprosy is still prevalent in Pakistan. Active case detection and awareness of doctors and community should be done for early diagnosis to prevent disabilities.
References
1. Reibel F, Cambau E, Aubry A. Update on the epidemiology, diagnosis, and treatment of leprosy. Med Mal Infect. 2015;45:383-93.
2. Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966;34:255-73.
3. The World Health Organization. Diagnosis of Leprosy. Leprosy Elimination. Available at http://www.who.int/lep/diagnosis/en/. Accessed: April 15, 2016.
4. Khan I, Khan AR, Khan MS. Clinico pathological study of %) patients in northern areas of Pakistan. J Pak Assoc Dermatol. 2012;22:200-6.
5. Oliveira MB, Diniz LM. Leprosy among children under 15 years of age: literature review. An Bras Dermatol. 2016;91:196-203.
6. van Beers SM, Hatta M, Klatser PR. Patient contact is the major determinant in incident leprosy: implications for future control. Int J Lepr Other Mycobact Dis. 1999:67:119-28.
7. Penna ML, Penna GO, Iglesias PC, Natal S, Rodrigues LC. Anti-PGL-1 Positivity as a risk marker for the development of leprosy among contacts of leprosy cases: systematic review and meta-analysis. PLoS Negl Trop Dis. 2016;10:e0004703.
8. Gaschignard J, Grant AV, Thuc NV, Orlova M, Cobat A, Huong NT et al. Pauci- and multibacillary leprosy: Two distinct,
genetically neglected diseases. PLoS Negl Trop Dis. 2016;10(5):e0004345.
9. Paschoal JAA, Paschoal VD, Nardi SMT, Rosa PS, Ismael MG, Sichieri EP. Identification of Urban Leprosy Clusters. Sci World J. 2013;2013:219143. doi:10.1155/2013/219143.
10. Lastória JC, de Abreu MAMM. Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1. An Bras Dermatol. 2014;89:205-18.
11. Shenoy SM, Shenoy MM. Mid-borderline leprosy. Indian Dermatol Online J. 2013;4(2):162.
12. Shumet T, Demissie M, Bekele Y. Prevalence of disability and associated factors among registered leprosy patients in All Africa TB and Leprosy Rehabilitation and Training Centre (ALERT), Addis Ababa, Ethiopia. Ethiopian J Health Sci. 2015;25:313-20.
13. Soomro FR, Pathan GM, Bajaj DR, Leprosy in Larkano region; an analysis of 102 cases from 2001-2011 at leprosy centre Larkano, Sindh, Pakistan. J Pak Assoc Dermatol. 2012;22:126-9.
14. Cabalar M, Yayla V, Ulutas S, Senadim S, Oktar AC. The clinical and neurophysiological study of leprosy. Pak J Med Sci. 2014;30:501-6.
15. Pandhi D, Chhabra N. New insights in the pathogenesis of type 1 and type 2 lepra reaction. Indian J Dermatol Venereol Leprol. 2013;79:739-49.
16. Scollard DM, Martelli CMT, Stefani MMA, Pardillo F et al. Risk Factors for leprosy reactions in three endemic countries. Am J Trop Med Hygiene. 2015;92:108-14.
17. Eichelmann K, González González SE, Salas-Alanis JC, Ocampo-Candiani J. Leprosy. An update: definition, pathogenesis, classification, diagnosis, and treatment. Actas Dermosifiliogr. 2013;104(7):554-63.
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Copyright (c) 2018 Rabia Ghafoor, Mutahir Zia, Muhammad Irfan Anwar, Mansoor Ahmed, Kanta Lal Kumar, Muhammad Iqbal

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