Correlation of Vitiligo Area Scoring Index with the amount of CXCL 10 serum in vitiligo patient
Keywords:
CXCL 10, VitiligoAbstract
Introduction Vitiligo is a skin pigmentation disorder, often progressive and familial, characterized by depigmented macules on asymptomatic skin. This disorder is an acquired idiopathic depigmentation disorder, characterized by scaly/ non-scaly white macules resulting from the loss of skin melanocytes. CXCL 10 is one of the 3 CXCR 3 receptor ligands which have chemotaxic effects on various immune system cells. Serum CXCL 10 can be a new biomarker in monitoring disease activity. Methods This is a descriptive cross-sectional study aimed at evaluating serum CXCL 10 levels in vitiligo patients conducted at Dr. Soetomo general hospital Surabaya, 16 blood samples of patients diagnosed with vitiligo were taken to patients to measure serum CXCL 10 levels. Results Serum CXCL 10 levels in this study were higher in patients with stable vitiligo lesion activity and had high VASI values statistically, p = 0.000 (p = < 0.05). Conclusion There is positive correlation between VASI score and CXCL 10 serum levels.ÂReferences
Birlea SA, Spritz RA, Norris DA. Vitiligo. Dalam: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Leffel DJ, editors. Fitzpatrick’s Dermatology General Medicine. 8th Ed. New York: McGraw Hill Co. 2013. p. 792-803.
Kutlubay Z, Karakus O, Engin B, Serdaroglu S. Vitiligo as autoimun disease. J Turk Acad Dermatol 2012;6(2):126r1.
Wang XX, Wang QQ, Wu JQ, Jiang M, Chen L, Zhang CF, et al. Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo. Br J Dermatol 2016; 174(6): 1318–26.
Antonelli A, Ferrari SM, Giuggioli D, Ferrannini E, Ferri C, Fallahi P. Chemokine (C-X-C motif) ligand (CXCL) 10 in autoimmune diseases. Autoimmunity reviews Elsevier 2014:272-80.
Rashighi M, Agarwal P, Richmond JM, Harris TH, Dresser K, Su MW, et al. CXCL is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo. Science Translational Medicine 2014; 6: 223.
