Correlation of Vitiligo Area Scoring Index with the amount of CXCL 10 serum in vitiligo patient

Authors

  • Ardhiah Iswanda Putri Airlangga University
  • Dr. Sawitri
  • Diah Mira Indramaya
  • M. Yulianto Listiawan

DOI:

https://doi.org/10.66344/jpad.29.3.2019.1296

Keywords:

CXCL 10, Vitiligo

Abstract

Introduction Vitiligo is a skin pigmentation disorder, often progressive and familial, characterized by depigmented macules on asymptomatic skin. This disorder is an acquired idiopathic depigmentation disorder, characterized by scaly/ non-scaly white macules resulting from the loss of skin melanocytes. CXCL 10 is one of the 3 CXCR 3 receptor ligands which have chemotaxic effects on various immune system cells. Serum CXCL 10 can be a new biomarker in monitoring disease activity. Methods This is a descriptive cross-sectional study aimed at evaluating serum CXCL 10 levels in vitiligo patients conducted at Dr. Soetomo general hospital Surabaya, 16 blood samples of patients diagnosed with vitiligo were taken to patients to measure serum CXCL 10 levels. Results Serum CXCL 10 levels in this study were higher in patients with stable vitiligo lesion activity and had high VASI values statistically, p = 0.000 (p = < 0.05). Conclusion There is positive correlation between VASI score and CXCL 10 serum levels. 

References

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Kutlubay Z, Karakus O, Engin B, Serdaroglu S. Vitiligo as autoimun disease. J Turk Acad Dermatol 2012;6(2):126r1.

Wang XX, Wang QQ, Wu JQ, Jiang M, Chen L, Zhang CF, et al. Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo. Br J Dermatol 2016; 174(6): 1318–26.

Antonelli A, Ferrari SM, Giuggioli D, Ferrannini E, Ferri C, Fallahi P. Chemokine (C-X-C motif) ligand (CXCL) 10 in autoimmune diseases. Autoimmunity reviews Elsevier 2014:272-80.

Rashighi M, Agarwal P, Richmond JM, Harris TH, Dresser K, Su MW, et al. CXCL is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo. Science Translational Medicine 2014; 6: 223.

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Published

2019-10-21

How to Cite

1.
Putri AI, Sawitri D, Indramaya DM, Listiawan MY. Correlation of Vitiligo Area Scoring Index with the amount of CXCL 10 serum in vitiligo patient. J Pak Assoc Dermatol [Internet]. 2019Oct.21 [cited 2026Apr.12];29(3):286-8. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/1296

Issue

Vol. 29 No. 3 (2019): July - September

Section

Original Articles

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Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.

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