Efficacy of narrowband ultraviolet B phototherapy with needling in patients of vitiligo
DOI:
https://doi.org/10.66344/jpad.25.3.2015.105Keywords:
Narrowband ultraviolet B therapy, needling, vitiligoAbstract
Objective To determine the efficacy of narrowband ultraviolet B therapy (NBUVB) with needling in patients of vitiligo. Methods A total of 100 cases were included in this study. In each patient a patch of 15 to 5 cm diameter skin area was selected as a target lesion for the study. Needling was done on the whole patch with a disposable insulin syringe, from the pigmented margins or the islands in the vitiliginous patch. After the procedure, the whole patch was subjected to NBUVB. The repigmentation was assessed according to 5-grades scale. Results Out of 100 patients of vitiligo, 45% males and 55 % females, treated with NBUVB with needling, 58% patients showed grade 4 response i.e. 75% or more repigmentation. Conclusion Narrowband UVB with needling is an effective, useful and well-tolerated therapy for treatment of vitiligo. ÂReferences
Forschner T, Buchholtz S, Stockfleth E. Current state of vitiligo therapy - evidence-based analysis of the literature. J Dtsch Dermatol. 2007;5:467-75.
Millington GWM, Levell NJ. Vitiligo; the historical curse of depigmentation. Int J Dermatol. 2007;46:990-5.
Gottschalk GM, Kidson SH. Molecular analysis of vitiligo lesions reveals sporadic melanocyte survival. Int J Dermatol. 2007;46:268-72.
Leite RMS, Leite AAC. Two therapeutic challenges. Periocular and genital vitiligo in children successfully treated with pimecrolimus cream. Int J Dermatol. 2007;46:986-9.
Savant SS. Introduction to vitiligo surgery. In: Savant SS, editor. Textbook of Dermatosurgery and Cosmetology, 2nd ed. Mumbai: ASCAD; 2005. p. 336.
Savant SS. Surgical therapy of vitiligo: Current status. Indian J Dermatol Venereol Leprol. 2005;71:307-10.
Ahmed TJ, Rashid T, Rani Z. Needling: an adjunct to narrowband ultraviolet B therapy in localized fixed vitiligo. J Pak Assoc Dermatol. 2008;18:149-53.
Westerhof W. The discovery of the human melanocyte. Pigment Cell Res. 2006;19:183-93.
Grimes PE. Diseases of hypopigmentation. In: Sams WM, Lynch PJ, editors. Principles and Practice of Dermatology. 2nd ed. New York: Churchill-Livingstone; 1996. p. 873-85.
Njoo MD, Bos JD, Westerhof W. Treatment of generalized vitiligo in children with narrow-band (TL-01) UVB radiation therapy. J Am Acad Dermatol. 2000;42:245-53.
Westerhof W, Nieuweboer-Krobotova L. Treatment of vitiligo with UV-B radiation vs. psoralen plus UV-A. Arch Dermatol. 1997;133:1525-8.
Savant SS. Therapeutic wounding. In: Savant SS, editor. Textbook of Dermatosurgery and cosmetology, 2nd ed. Mumbai: ASCAD; 2005. p. 370-7.
Yones SS, Palmer RA, Garibaldinos TM, Hawk JL. Randomized double-blind trial of treatment of vitiligo: efficacy of psoralen-UV-A therapy vs Narrowband-UV-B therapy. Arch Dermatol. 2007;143:578-84.
Scherschun L, Kim JJ, Lim HW. Narrow-band ultraviolet B is a useful and well-tolerated treatment for vitiligo. J Am Acad Dermatol. 2001;44:999-1003.
Njoo MD, Spuls PI, Bos JD. Nonsurgical repigmentation therapies in vitiligo: meta-analysis of the literature. Arch Dermatol. 1998;134:1532-40.
Papadopoulos L, Walker C, Anrhis L. Living with vitiligo: a controlled investigation into the effects of group cognitive behavioural and person-centred therapies. Dermatol Psychosom. 2004;5:172-7.
Mohaghegh F, Asilian A, Faghihi F, Adibi N. A Comparison between the efficacy of narrow band ultra violet B phototherapy with and without needling of the lesion in the treatment of vitiligo. J Res Med Sci. 2012;17(Spec 1): S131-S133.
Wassef C, Lombardi A, Khokher S, Rao BK. Vitiligo surgical, laser, and alternative therapies: A review and case series. J Drugs Dermatol. 2013;12:685-69.
Downloads
Published
How to Cite
Issue
Section
License
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.