Prevalence of smoking, alcohol, and comorbid conditions in psoriasis

Authors

  • Ghazala Aziz Khan
  • Lamees Mahmood Malik
  • Muhammad Jahangir

Keywords:

Psoriasis, smoking, alcohol, comorbid conditions

Abstract

Background Numerous studies suggest a link between cigarette smoking and alcohol. Psoriasis is associated with comorbid conditions like diabetes, hypertension, and metabolic syndromes which have a major impact on severely affected patients. Objective To study and assess frequency of smoking, alcohol, and comorbid conditions in patients of psoriasis. Patients and methods One hundred and four psoriatic patients fulfilling the inclusion criteria, were included in the study. Detailed medical history and examination of the patients with particular emphasis on the onset, distribution, and nature of psoriasis was carried out. History of smoking and alcohol intake was specifically looked for along with known history of other medical ailments. Diagnosis of psoriasis was clinical. Results Out of 104 patients 58% were males and 42% were females. Mean age was 34.8+14.71 years. Most of the patients had generalized type of plaque psoriasis. Among all, 26.9% were smokers. History of alcohol intake was found only in 2.9% of patients. Comorbid diseases noted were hypertension and diabetes present in 11.6% and 5.8%, respectively. 3.9% were positive for hepatitis C virus. Conclusion In our study, smoking was associated with severity of disease and mean PASI scores directly correlated with the number of pack years. Data regarding alcohol are still scanty and larger number of patients is required to establish or refute an association. Comorbidities in psoriasis may need careful assessment and early treatment. 

References

Gelfand JM, Weinstein R. Steven B, Porter, BA. Prevalence and treatment of psoriasis in the United Kingdom. Arch Dermatol 2005; 141, 1537-46

Herron MD, Hinckley M. Impact of obesity and smoking on psoriasis presentation and management. Arch Dermatol 2005; 141:1527-34.

Bajaj DR, Mahesar SM, Devrajani BR, Iqbal MP. Lipid profile in patients with psoriasis. J Pak Med Assoc 2009; 59: 512-5.

Setty AR, Curhan G. Smoking and the risk of psoriasis in women: Nurses, Health Study II. Am J Med 2007; 120: 953-9.

Lahmann C, Bergemann J, Harrison G, Young AR. Smoking and the Skin. Lancet 2001; 24: 935-6.

Williams HC. Smoking and psoriasis. BMJ 1994; 308: 428-9.

Jankovic S, Raznatovic M, Marinkovic J et al. Risk factors for psoriasis. J Dermatol 2009; 36: 328-34.

Naldi L, Parazzini F, Brevi A. Family history, smoking habits, alcohol consumption and risk of psoriasis. Br J Dermatol 2006; 127: 212-7.

Huerta C, Rivero E, Luis A. Rodriguez G. Incidence and risk factors for psoriasis in the general population. Arch Dermatol 2007; 143: 1559-65.

Behnam SM, Behnam SE, Koo JY. Alcohol as a risk factor for plaque-type psoriasis. Cutis 2005; 76: 181-5.

Poikolainen K, Reunala T, Karavonen J. Smoking, alcohol and life events related to psoriasis among women. Br J Dermatol 2006; 130: 473-7.

Poikolainen K, Karvonen J, Pukkala E. Excess mortality related to alcohol and smoking among hospital-treated patients with psoriasis. Arch Dermatol 1999; 135: 1490-3.

Fortes C, Mastroeni S. Relationship between smoking and the clinical severity of psoriasis. Arch Dermatol 2005; 141: 1580-4.

Naldi L, Peli L, Parazzini F. Association of early stage psoriasis with smoking and male alcohol consumption: evidence from an Italian case control study. Arch Dermatol 1999; 135: 1479-84.

Byron KA. Varigos GA, Wooton AM. IL-4 production is increased in cigarette smokers. Clin Exp Immunol1994; 95: 333-6.

Ryder MI, Saghizaden M, Ding Y et al. Effect of tobacco smoke on the secretion of interleukin-1β, tumor necrosis factor-α and transforming growth factor-β from peripheral blood mononuclear cells. Oral Microbiol Immunol 2002: 17: 331-6.

Al-Mutairi N, Al-Farag S, Al-Mutairi A, Al-Shiltawy M. Comorbidities associated with psoriasis. J Dermatol 2010; 37: 146-55.

Ayala F, Ayala F. Clinical aspects and comorbidities of psoriasis. J Rheumatol 2009; 83 (Suppl): 19-20.

Donald W. Immunological effects of tobacco smoking in “healthy” smokers. COPD. J Chr Obstr Pulm Dis 2009; 6: 48-58.

Dreiher M. Research on chronic obstructive pulmonary disease. Br J Dermatol 2008; 159: 956-60.

Qureshi AA. Psoriasis and the risk of diabetes and hypertension. Arch Dermatol 2009; 145: 379-9.

Binazzi M, Calandra P, Lisi P. Association between psoriasis and diabetes. Arch Dermatol Res1975; 254: 43-8.

Hussain I, Haroon TS. Comorbidities in psoriasis and their therapeutic implications. J Pak Assoc Dermatol 2009; 19: 63-5.

Rao R, Prabhu S, Sripathi H. Co-occurrence of psoriases and occlusive vascular disease. Indian J Dermatol Venereol Leprol 2008; 74; 399-401.

Downloads

Published

2016-12-21

How to Cite

1.
Khan GA, Malik LM, Jahangir M. Prevalence of smoking, alcohol, and comorbid conditions in psoriasis. J Pak Assoc Dermatol [Internet]. 2016Dec.21 [cited 2024Feb.26];20(4):212-6. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/379

Issue

Section

Original Articles

Most read articles by the same author(s)

1 2 3 4 > >>