Comparison of efficacy of intralesional 5-fluorouracil alone versus intralesional triamcinolone acetonide with 5-fluorouracil in small keloids

Authors

  • Afshan Sagheer
  • Atif Shehzad
  • Ijaz Hussain

Keywords:

Intralesional 5-fluorouracil, small keloids, triamcinolone acetonide

Abstract

Objective To evaluate the efficacy of intralesional 5-fluorouracil alone in comparison with the combination of intralesional triamcinolone acetonide and 5-fluorouracil in treatment of small keloids. Methods Sixty patients who fulfilled the inclusion and exclusion criteria were recruited. Patients were randomly divided into two groups. In group A, intralesional 5-fluorouracil 50 mg/ml was used. In group B, combination of triamcinolone acetonide 40mg/dl (0.1ml) and 5-fluorouracil 50mg/ml (0.9ml) was used, on monthly basis for 6 months. Patients were assessed for efficacy, after 6 months of the treatment. Results Efficacy was achieved in 32 cases in which 10 (33.3%) cases were from 5-FU group and 22 (73.3%) were from 5-FU+steroid group, which was statistically significant (p=0.002.). Conclusion In the treatment of small keloids the combination of 5-FU + steroid has better efficacy in comparison with 5-FU alone. 

References

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Published

2017-04-12

How to Cite

1.
Sagheer A, Shehzad A, Hussain I. Comparison of efficacy of intralesional 5-fluorouracil alone versus intralesional triamcinolone acetonide with 5-fluorouracil in small keloids. J Pak Assoc Dermatol [Internet]. 2017Apr.12 [cited 2024Nov.3];26(4):361-5. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/970

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