Comparison of efficacy of intralesional 5-fluorouracil alone versus intralesional triamcinolone acetonide with 5-fluorouracil in small keloids
DOI:
https://doi.org/10.66344/jpad.v26i4.970Keywords:
Intralesional 5-fluorouracil, small keloids, triamcinolone acetonideAbstract
Objective To evaluate the efficacy of intralesional 5-fluorouracil alone in comparison with the combination of intralesional triamcinolone acetonide and 5-fluorouracil in treatment of small keloids.
Methods Sixty patients who fulfilled the inclusion and exclusion criteria were recruited. Patients were randomly divided into two groups. In group A, intralesional 5-fluorouracil 50 mg/ml was used. In group B, combination of triamcinolone acetonide 40mg/dl (0.1ml) and 5-fluorouracil 50mg/ml (0.9ml) was used, on monthly basis for 6 months. Patients were assessed for efficacy, after 6 months of the treatment.
Results Efficacy was achieved in 32 cases in which 10 (33.3%) cases were from 5-FU group and 22 (73.3%) were from 5-FU+steroid group, which was statistically significant (p=0.002.).
Conclusion In the treatment of small keloids the combination of 5-FU + steroid has better efficacy in comparison with 5-FU alone.
References
1. Köse O, Waseem A. Keloids and hypertrophic scars; are they two different sides of the same coin? Dermatol Surg. 2008;34:336-46.
2. Bollero D, Malvasio V, Catalano F, Stella M. Negative pressure surgical management after pathological scar surgical excision: a first report. Int Wound J. 2015;12:17-21.
3. Kischer C, Brody G. Structure of the collagen nodule from hypertrophic scars and keloids. Scan Electr Microscop. 1980 (Pt 3):371-6
4. Prabhu A, Sreekar H, Powar R, Uppin V. A randomized controlled trial comparing the efficacy of intralesional 5-fluorouracil versus triamcinolone acetonide in the treatment of keloids. J Sci Soc. 2012;39(1):19.
5. Darougheh A, Asilian A, Shariati F. Intralesional triamcinolone alone or in combination with 5‐fluorouracil for the treatment of keloid and hypertrophic scars. Clin Experiment Dermatol. 2009;34:219-23.
6. Davison SP, Dayan JH, Clemens MW, Sonni S, Wang A, Crane A. Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids. Aesthet Surg J. 2009;29:40-6.
7. Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W et al. Human infection with a novel avian-origin influenza A (H7N9) virus. New Engl J Med. 2013;368:1888-97.
8. Wu X, Gao Z, Song N, Liu W. Clinical study of auricular keloid treatment with both surgical excision and intralesional injection of low-dose 5-fluorouracil and corticosteroids. Zhonghua Yi Xue Za Zhi. 2009;89:1102-5.
9. Alhady SM, Sivanantharajah K. Keloids in various races. A review of 175 cases. Plast Reconstr Surg. 1969;44:564-6.
10. Gupta S, Kalra A. Efficacy and safety of intralesional 5-fluorouracil in the treatment of keloids. Dermatology. 2002;204:130-2.
11. Sharma S, Bassi R, Gupta A. Treatment of small keloids with intralesional 5-fluorouracil alone vs. intralesional triamcinolone acetonide with 5-fluorouracil. J Pak Assoc Dermatol. 2012;22:35-40.
12. Khan MA, Bashir MM, Khan FA. Intralesional triamcinolone alone and in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. J Pak Med Assoc. 2014;64:1003-7.
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Copyright (c) 2017 Afshan Sagheer, Atif Shehzad, Ijaz Hussain
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