Frequency of superficial fungal infections in renal transplant recipients
Keywords:
Fungal infection, renal transplant, candidiasis, dermatophytosesAbstract
Objectives To determine the frequency of superficial fungal infections in renal transplant recipients.Methods This cross-sectional study was conducted in the outpatient clinic, Department of Dermatology, Dow University of Health Sciences & Civil Hospital Karachi. Patients of 20-60 year of age undergone renal transplant 3 to 12 months back were enrolled while patients with diabetes were excluded from study. Patients were evaluated for the presence of superficial mycoses. Skin scrapings and nail clippings were collected mycologic evaluation.Results A total of 62 patients were enrolled. The mean age of enrolled patients was 39.9±10.3 years and 37 (59.7%) were male. The mean duration of transplant was 7.6±2.9 months. 23 (37.1%) were on steroids. Fungal infections were documented in 38 (61.3%) patients. Of 38 patients, 19 (50%) had candidiasis. Stratified analysis showed fungal infections to be similar in ≥40 or <40 years of age (63.6% v. 58.6%), female and male (64% vs. 59.5%); duration of transplant <8 or >8 months (63.9% vs. 57.7%) and those who were on steroids (69.6%) or other drugs (62.5%).Conclusion It is concluded from this study that patient’s undergone renal transplant has increased frequency of fungal infection.References
Foster KW, Ghannoum MA, Elewski BE. Epidemiologic surveillance of cutaneous fungal infection in the United States from 1999 to 2002. J Am Acad Dermatol. 2004;50:748-52.
Kurnatowska I, Chrzanowski W, Kacprzyk F, Kurnatowska A. Multifocal fungal infections in patients after renal transplantation undergoing immunosuppression. Pol Merkur Lekarski. 2003;15:388-90.
Tan HH. Superficial fungal infections seen at the National Skin Centre, Singapore. Nippon Ishinkin Gakkai Zasshi. 2005;46:77-80.
Blohme I, Larkö O. Skin lesions in renal transplant patients after 10-23 years of immunosuppressive therapy. Acta Derm Venereol. 1990;70:491–4.
Bencini PL, Montagnino G, Sala Fet al. Cutaneous lesions in 67 cyclosporin-treated renal transplant recipients. Dermatologica. 1986;172:24-30
Seçkin D, Güleç TO, Emira A, Bilgin N. Renal transplantation and skin diseases. Transplant Proc. 1998;30:802-4.
Formicone F, Fargnoli MC, Pisani F et al. Cutaneous manifestations in Italian kidney transplant recipients. Transplant Proc. 2005;37:2527-8.
Badiee P, Kordbacheh P, Alborzi A et al. Fungal infections in solid organ recipients. Exp Clin Transplant. 2005;3:385-9.
Güleç AT, Demirbilek M, Seçkin D et al. Superficial fungal infections in 102 renal transplant recipients: a case-control study. J Am Acad Dermatol. 2003;49:187-92.
Pierard GE, Arrese JE. Treatment and prophylaxis of tinea infections. Drugs. 1996;52:209-24.
Rezabek GH, Friedman AD. Superficial fungal infections of the skin. Diagnosis and current treatment recommendations. Drugs. 1992;43:674-82.
George L, John GT, Jacob CK et al. Skin lesion in renal transplant recipient: a single center study. Indian J Derm Venerol Leprol. 2009;75:255-61
Vijaykumar R, Fernando E, Rajendran S et al. Dermatological manifestations in renal transplant recipients. Transpl Proc. 1998;30:313-5.
