Necrobiotic xanthogranuloma – a case report

Authors

  • Muhammad Munir Rashid
  • Tamanna Chowdhury
  • Abida Sultana
  • Rokeya Begum
  • Shiropa Islam
  • Iftekhar Ahmed

DOI:

https://doi.org/10.66344/jpad.19.3.2009.537

Keywords:

Necrobiotic xanthogranuloma

Abstract

We report here a 70-year-old lady with multiple large soft yellowish plaques around her eyes for last 10 years. Histopathological evaluation revealed a dense histiocytic infiltrate with hyaline necrobiosis involving the dermis with extension to the subcutis. Multiple large multinucleated giant cells and scattered lymphocytes were seen. Serum protein electrophoresis revealed nonspecific findings. Based on the clinical picture, and histopathology results, a diagnosis of necrobiotic xanthogranuloma was made. 

References

Kossard S, Winkelmann RK. Necrobiotic xanthogranuloma. Australas J Dermatol 1980; 21: 85-8.

James WD, Berger TG, Elston DM, eds. Andrew’s Disease of the Skin. Philadelphia: Saunders Elsevier; 2006, p 707-8.

Wee SA, Shupack JL. Necrobiotic xanthogranuloma. Dermatology Online Journal 2005; 11: 24.

Mehregan DA, Winkelmann RK. Necrobiotic xanthogranuloma. Arch Dermatol 1992; 128: 94.

Winkelmann RK, Litzow MR, Umbert IJ, Lie JT. Giant cell granulomatous pulmonary and myocardial lesions in necrobiotic xanthogranuloma with paraproteinaemia. Mayo Clin Proc 1997; 72: 1028-33.

Necrobiotic xanthogranuloma. Wolff K, Goldsmith LA, Katz SI et al. (eds). Dermatology in General Medicine, 7th Edn. Philadelphia: McGraw-Hill; 2008. P. 1432-3.

Matsuura F, Yamashita S, Hirano K et al. Activation of monocytes in vivo causes intracellular accumulation of lipoprotein-derived lipids and marked hypercholesterolemia: a possible pathogenesis of necrobiotic xanthogranuloma. Atherosclerosis 1999; 142: 355-65

Finan MC, Winkelmann RK. Necrobiotic xanthogranuloma with paraproteinaemia: a review of 22 cases. Medicine 1986; 65: 376-88.

Venencie PY, Le Bras P, Toan ND et al. Recombinant interferon alpha-2b treatment of necrobiotic xanthogranuloma with paraproteinaemia. J Am Acad Dermatol 1995; 32: 666-7.

Downloads

Published

2016-12-24

How to Cite

1.
Rashid MM, Chowdhury T, Sultana A, Begum R, Islam S, Ahmed I. Necrobiotic xanthogranuloma – a case report. J Pak Assoc Dermatol [Internet]. 2016Dec.24 [cited 2026Apr.21];19(3):175-7. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/537

Issue

Vol. 19 No. 3 (2009): July - September

Section

Case Reports

License

Submission declaration

Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.

By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.

Most read articles by the same author(s)