Non langerhans cell histiocytoses in genitalia: A rare entity

Authors

  • Shiladitya Chowdhury Medical College Kolkata, West Bengal, India
  • Dyuti Das Medical College Kolkata, West Bengal, India
  • Prodip Sarkar Medical College Kolkata, West Bengal, India
  • Supratim Karmakar Medical College Kolkata, West Bengal, India
  • Partha Sarathi Nayak Medical College Kolkata, West Bengal, India
  • Ramesh Chandra Gharami Medical College Kolkata, West Bengal, India

DOI:

https://doi.org/10.66344/jpad.34.3.2024.2581

Keywords:

Non-Langerhans cell, cyclophosphamide, immunohistochemistry

Abstract

A 35 year old man presented with multiple reddish to skin colored scrotal swellings for the last 8 to 10 months. On biopsy, well circumscribed dense nodular infiltrate composed of histiocytes, lymphocytes and stray plasma cells. On IHC: CD 68 +ve, but CD1a, S100, Langerin, BRAFV600E, CD30 were negative. Based on HPE and IHC reports, a diagnosis of non-Langerhans cell histiocytosis was made. Initially the lesions were treated with intra-lesional corticosteroids, without any significant improvement. As a newer therapy, we tried oral cyclophosphamide 50 mg BD for 2 months, followed by 50 mg OD as maintenance dose, no new lesions were noted.

References

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doi: 10.1016/j.jaad.2006.06.010. Epub 2006 Oct 9. PMID: 17097374.

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Published

2024-07-02

How to Cite

1.
Chowdhury S, Das D, Sarkar P, Karmakar S, Nayak PS, Gharami RC. Non langerhans cell histiocytoses in genitalia: A rare entity. J Pak Assoc Dermatol [Internet]. 2024Jul.2 [cited 2026Apr.12];34(3):749-51. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/2581

Issue

Vol. 34 No. 3 (2024): July-September

Section

Case Reports

License

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