Herpetiform dermatitis: A case report
DOI:
https://doi.org/10.66344/jpad.34.4.2024.2478Keywords:
Herpetiform dermatitis, Morbus duhring, Autoimmune skin disease, IgA autoantibodyAbstract
Herpetiform dermatitis (HD) also known as 'morbus duhring' is a chronic autoimmune skin disease that causes severe itching. This condition is associated with antitransglutaminase IgA autoantibody on the superficial papillary dermis layer that causes neutrophil infiltration and blister formation. Formerly, it was explained by American dermatologist, Louis Adolphus Duhring in 1884. This disease is characterized by papules, vesicles, plaques, urticaria, erythema, and excoriations that vary from 1–3 mm, mainly located on the extensor areas of the upper and lower extremities, shoulders, mid-back, and buttocks that are symmetrically distributed. HD is known to be associated with gluten-sensitive enteropathy (GSE) or celiac disease (CD) which is believed to play an important role in its pathogenesis. More than 90% of HD patients are shown to be gluten-sensitive. This case report investigates HD’s clinical characteristics and association with GSE or CD in a defined patient population.References
Kárpáti S. Dermatitis herpetiformis. Clin Dermatol. 2012;30(1):56-9.
Salmi T. Hervonen K. Current concept of dermatitis herpetiformis. Acta Derm Venereol. 2020;100:adv00056.
Widyastuti S, Sari N, Rinawati W, Wardhana M, Adiguna MS. Terapi Dapson Pada Dermatitis Herpetiformis. Media Dermato-Venereologica Indonesiana. Available from: URL: http://www.perdoski.or.id/doc/mdvi/fulltext/36/241/10_ Tinjauan_Pustaka_1.pdf
Caproni M, Antiga E, Melani L, Fabbri P. Guidelines for the diagnostic and treatment of dermatitis herpetiformis. JEADV. 2009;23:633-8.
Vale ECS, Dimatos OC, Porro AM, Santi CG. Consensus on the treatment of autoimmune bullous dermatoses: dermatitis herpetiformis and linear IgA bullous dermatosis– Brazilian Society of Dermatology. An Bras Dermatol. 2019;94 (2 Suppl 1):S48-55.
Salmi T. Dermatitis herpetiformis. Clin Exp Dermatol. 2019;44: 728–31.
Antiga E, Maglie R, Quintarelli L, Verdelli A, Bonciani D, Bonciolini V, Caproni M. Dermatitis Herpetiformis: Novel Perspectives. Front Immunol. 2019;10:1290.
Alonso JJ, Gibson LE, and Rogers III RS. Clinical, pathologic, and immunopathologic features of dermatitis herpetiformis: review of the Mayo Clinic experience. Int J Dermatol. 2007;46:910-9.
Bolotin D, Petronic-Rosic V. Dermatitis herpetiformis. Part II. Diagnosis, management, and prognosis. J Am Acad Dermatol. 2011;64(6):1027-34.
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