Comparison of outcome of microneedling with autologus platelet rich plasma verses microneedling with topical insulin in the treatment of post-acne atrophic scars
DOI:
https://doi.org/10.66344/jpad.v33i4.2378Keywords:
Acne vulgaris, Micro-needling, Platelet Rich Plasma, Insulin, Post-acne atrophic scarAbstract
Objective To compare the outcome of micro-needling with autologous platelet rich plasma versus micro-needling with topical insulin in the treatment of post-acne atrophic scars.
Methods 80 patients fulfilling the inclusion criteria were enrolled. Goodman and Baron’s Qualitative Scarring Grading System was used to calculate grade at enrollment and at a monthly interval for total 4 sessions and follow up visit after 2 months of last session. Following micro-needling with a derma roller, topical applications of 2ml of human actrapid insulin was done in group-A and 2ml of PRP in group-B. Percentage reduction of acne scar grade was calculated. Data was analyzed in SPSS v25.0. Chi-square test was applied for Comparison of outcomes in terms of post-treatment percentage reduction of grades from patient’s baseline grade. P-value of <0.05 was considered significant.
Results Males and females were 10(25.0%) and 30(75.0%) respectively in group-A, while 13(32.5%) males and 27(67.5%) females were enrolled in group-B. The mean age of patients was 23.68±5.03 years and 24.48±4.75 years in group-A and B correspondingly. The mean duration of scar was 4.5±2.1 years in group A and 4.9±2.3 years in group B. In group A the mean exposure to sunlight was 4.9±2.3hours and in group B was 4.7±2.1hours. Mean percentage reduction of grades of scar in group-A was 55.42±12.74% and 23.33±16.79% in group-B.
Conclusion Micro-needling with insulin has more efficacy than micro-needling with Platelet Rich Plasma in treating acne scars. This combined procedure is cost effective, favourable for all skin types with minimal post-inflammatory hyperpigmentation. Also this novel combination procedure is convenient for both doctors and patients as no high skills are required, no need to take I/V line and less time consuming.
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Copyright (c) 2023 Sara Mubeen, Syed Ahmed Ali Gardezi, Aisha Ghias, Eima Shaheen, Zaima Sohail Chaudhry, Shahbaz Aman
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