Effects of acne management therapies on the levels of microRNAs and acne severity index- A randomized clinical trial
Acne Management therapies on levels of microRNAs
Abstract
Introduction The study was aimed to identify the effects of acne treatment protocols to determine their impact on levels of miRNA and acne severity index of acne vulgaris patients after three months of treatment protocol. Methodology The outcome measures were analyzed on two parameters; levels of miRNA and acne severity index. The outcome parameters were recorded twice at baseline; before the start of the treatment session and after completion of 3 months of treatment session. Extraction of miRNA was performed from serum samples of patients using a TRIzol LS method. Results It was estimated that isotretinoin was turned out to be effective in lowering the value of hsa-mir-223, hsa-mir-21, has-mir-155 and hsa-mir-4273 in comparison to topical clindamycin and IPL therapy whereas IPL treatment was turned out to be significantly better than clindamycin in lowering the value of hsa-mir-21. Conclusion The study had concluded that levels of microRNAs rises among acne vulagris patients and that administration of isotretinoin significantly reduces the levels of miRNA. Key words: Acne Vulgaris, MicroRNAs, isotretinoin, clindamycin & Polymerase Chain ReactionReferences
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