Multiple trichoepithelioma: A case report

Authors

  • Sebastian Hendry Wibowo Dermatology and Venereology Department, Faculty of Medicine Sam Ratulangi University
  • Sthefanie Mariska Gaghana Department of Dermatology and Venereology, Prof. dr. R.D. Kandou Central General Hospital/ Faculty of Medicine Sam Ratulangi University, Manado, North Sulawesi, Indonesia
  • Pieter Levinus Suling Department of Dermatology and Venereology, Prof. dr. R.D. Kandou Central General Hospital/ Faculty of Medicine Sam Ratulangi University, Manado, North Sulawesi, Indonesia
  • Shienty Gaspersz Department of Dermatology and Venereology, Prof. dr. R.D. Kandou Central General Hospital/ Faculty of Medicine Sam Ratulangi University, Manado, North Sulawesi, Indonesia
  • Thigita Aga Pandaleke Department of Dermatology and Venereology, Prof. dr. R.D. Kandou Central General Hospital/ Faculty of Medicine Sam Ratulangi University, Manado, North Sulawesi, Indonesia

Keywords:

Multiple trichoepithelioma, electrosurgery, dermoscopy

Abstract

Multiple trichoepithelioma is a skin tumor disease caused by mutation in the CYLD gene on chromosome 16 which is inherited through an autosomal dominant manner. This disease mostly occurs in female population aged 10 to 20 years. Treatment for this disease including: excision of the lesion or ablation modalities with electrosurgery, cryosurgery and laser or topical imiquimod. A 9-year-old woman was diagnosed with multiple trichoepithelioma through anamnesis, physical examination and dermoscopy, which revealed a millia-like cyst and telangiectasia on one of the lesions from patient's face. Electrosurgery was performed to partially remove the lesions on the patient's face. The patient then being given an antibiotic cream as a postoperative wound care. Multiple trichoepithelioma is a benign tumor which is a variation of cribriform trichoblastoma with differentiation from infundibulocystic. Multiple trichoepithelioma presents as painless multiple well-defined skin-colored, pink, or bluish papules, mostly on the face symmetrically. Electrosurgery was performed in this case. On the 36th day of observation, there were no postoperative complications or new papules. We report a case of multiple trichoepithelioma in a 9-year-old girl who was treated with electrosurgery.

References

Foreman RK, Duncan LM. Appendage Tumors of the Skin : Trichoepithelioma and Desmoplastic Trichoepithelioma. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer JS, editor : Fitzpatrick’s dermatology in general medicine. 9th Edition. New York:McGraw Hill Companies; 2019.p. 1841.

James WD, Elston D, Treat JR, Rosenbach MA, Neuhaus IM. Brooke-Spiegler Syndrome (Multiple Familial Trichoepithelioma, Epithelioma Adenoides Cysticum). In: Andrews’ Disease of the Skin Clinical Dermatology Thirteenth Edition. Penssylvania: Elsevier Inc. 2020.p. 673 - 674.

McCalmont TH, Pincus LB. Trichoepithelioma/ trichoblastoma. In: Bolognia JL, Jorrizo JL, Schaffer JV, Callen JP, Lorenzo C, Heymann WR, et al., editor: Dermatology Fourth Edition. United States of America : Elsevier Inc; 2018.p. 1936 - 1938.

Mohammadi AA, Jafari SMS. Trichoepithelioma: A Rare but Crucial Dermatologic Issue. World J Plast Surg. 2014;3(2):142-5.

Lazaridou E, Fotiadou C, Patsatsi A, Fotiadou A, Kyrmanidou E, Kemanetzi C, et al. Solitary trichoepithelioma in an 8-year-old child: clinical, dermoscopic and histopathologic findings. Dermatol Pract Concept. 2014;4(2):55-8.

Navarrete-Dechent C, Bajaj S, Marghoob A, Gonzalez S, Munoz D. Multiple familial trichoepithelioma: confirmation via dermoscopy. Dermatol Pract Concept. 2016;6(3):51-4.

Kunz M, Kerl K, Braun RP. Basal Cell Carcinoma Mimicking Desmoplastic Trichoepithelioma: A Case with Correlation of Dermoscopy and Histology. Case Rep Dermatol. 2018;10(2):133-7.

Tunçel D, Yılmaz Özgüven B, Sarı AG, Karasoy Yeşilada A, Kabukçuoğlu F, Eken KG. Non-familial Multiple Trichoepithelioma: A Case Report. Meandros. 2020;21(2):155-8.

Karimzadeh I, Namazi MR, Karimzadeh A. Trichoepithelioma: A Comprehensive Review. Acta Dermatovenerol Croat. 2018;26(2):162-5.

Lobo Y, Blake T, Wheller L. Management of multiple trichoepithelioma: A review of pharmacological therapies. Australas J Dermatol. 2021;62(2):e192-e200.

Okamura S, Oyama N, Hasegawa M. The first case report of multiple familial trichoepitheliomas responding successfully to topical benzoyl peroxide: A possible therapeutic action underlying structural turnover and antiinflammation. Indian J Dermatol. 2022;67(1):67.

Downloads

Published

2023-03-05

How to Cite

1.
Wibowo SH, Sthefanie Mariska Gaghana, Pieter Levinus Suling, Shienty Gaspersz, Thigita Aga Pandaleke. Multiple trichoepithelioma: A case report. J Pak Assoc Dermatol [Internet]. 2023Mar.5 [cited 2025Jan.18];33(1):322-5. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/2020

Issue

Section

Case Reports