An Acrodermatitis continua of hallopeau evolving into generalized pustular psoriasis: A case series
DOI:
https://doi.org/10.66344/jpad.v32i2.1873Abstract
Acrodermatitis continua of Hallopeau (ACH) is considered as a variant of localized pustular psoriasis which involves fingertip and nail. ACH is rarely reported to evolve into generalized pustular psoriasis (GPP). This paper reports 3 cases of GPP which initially manifested as ACH. The aim of this report is to increase clinician awareness of localized pustular psoriasis history in a case with GPP and to review a concept of clinical course of ACH and its relation with GPP. Three patients diagnosed as ACH, with generalized manifestation of multiple pustules in underlying erythematous base. Based from clinical manifestation and histopathology examination, all of them was diagnosed as GPP. GPP was already known to have genetic predisposition, with mutation in gene IL36RN, CARD14, and APS13 have been documented in patient with GPP. The same genetic mutation in ACH was considered as the reason why this manifestation of localized pustular psoriasis could evolve into GPP. GPP could be preceded by manifestation of ACH. Clinician should ask for history of localized pustular psoriasis when met with a case of GPP.
References
1. Johan R, Hamzah RA. Gejala Klinis dan Terapi Psoriasis Pustulosa Generalisata tipe von Zumbuch. Cermin Dunia Kedokt. 2016;43(2):117-22.
2. Gudjonsson JE, Elder JT. Psoriasis. In: Kang S, Amagai M, Bruckner A, editors. Fitzpatrick’s Dermatology. 9th ed. New York: McGraw-Hill Education; 2019. p. 457-97.
3. Megasasi Y, Brahmanti H, Kumala YD, Manggala G. Acrodermatitis Continua of Hallopeau yang memberi respons baik terhadap terapi kombinasi salep klobetasol propionat 0,05% dan dapson. Media Dermato-Venereologica Indones. 2018; 45(1):18-24.
4. Alorainy M, Alshaya M, Ayesh M, Alsaif F, Al-rikabi A. Acrodermatitis Continua of Hallopeau with Bone Resorption in an 8-Year-Old Patient : A Case Report. Case Rep Dermatol. 2017;9:259-64.
5. Smith MP, Ly K, Thibodeaux Q, Bhutani T, Liao W, Beck KM. Acrodermatitis continua of Hallopeau : clinical perspectives. Psoriasis Target Ther. 2019;9:65-72.
6. Burden AD, Kirby B. Psoriasis and Related Disorders. In: Griffiths CEM, Barker J, Bleiker T, Chalmers R, Creamer D, editors. Rook’s Textbook of Dermatology. 9th ed. Chichester: Wiley Blackwell; 2016. p. 35.1-35.48.
7. Kioka M, Yu A, Tanizaki H, Kokunai Y. Acrodermatitis continua of Hallopeau successfully treated only with infliximab : A case report. J Cutan Immunol Allergy. 2018;1:73-6.
8. Sadlier M. Acrodermatitis continua of Hallopeau and geographic tongue are variants of pustular psoriasis. JAAD Case Reports. 2018;4(3):277.
9. Kim KH, Kim HL, Suh HY, Jeon JW, Ahn JY, Park MY, et al. A Case of Acrodermatitis Continua Accompanying with Osteolysis and Atrophy of the Distal Phalanx That Evoluted into Generalized Pustular Psoriasis. Ann Dermatol. 2016;28(6):794-5.
10. Ranugha PSS, Kumari R, Thappa DM. Acrodermatitis Continua of Hallopeau Evolving into Generalised Pustular Psoriasis. Indian J Dermatol. 2013;58(2):161-2.
11. Abbas O, Itani S, Ghosn S, Kibbi AG, Fidawi G, Farooq M, et al. Acrodermatitis Continua of Hallopeau Is a Clinical Phenotype of DITRA : Evidence that it is a variant of pustular psoriasis. Dermatology. 2013;226:28-31.
12. Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R, et al. Clinical and genetic differences between pustular psoriasis subtypes. J Allergy Clin Immunol. 2019;143(3):1021-7.
13. Hoegler KM, John AM, Handler MZ, Schwartz RA. Generalized pustular psoriasis: a review and update on treatment. J Eur Acad Dermatology Venereol. 2018;32(10):1645-51.
14. Ly K, Beck KM, Smith M, Thibodeaux Q, Bhutani T. Diagnosis and screening of patients with generalized pustular psoriasis. Psoriasis Target Ther. 2019;9:37-42.
15. Crowley EL, Maliyar K, Rodriguez-bolanos F, Toole AO, Gooderham MJ. Acrodermatitis continua of Hallopeau successfully treated with adalimumab : A case report. SAGE Open Med Case Reports. 2019;7:1-4.
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