An Psoriasis In HIV Patients: A Paradox
Psoriasis In HIV Patients: A Paradox
DOI:
https://doi.org/10.66344/jpad.v32i1.1846Abstract
Human immunodeficiency virus (HIV) infection is associated with increased susceptibility to skin disorders, including psoriasis. The exacerbation of psoriasis in severe advanced HIV is paradoxical. A 26-year-old man with HIV who had been diagnosed with psoriasis ten months before the diagnosis of HIV. The skin biopsy results indicated psoriasis vulgaris with a tissue CD4/CD8 ratio of 0/34. The initial CD4 count was 130 cells/L. The patient received ARV and topical steroids. There was a clinically significant rise in blood CD4 and tissue CD4/CD8 ratio in three-month follow-up. There are several hypotheses was proposed to explain the pathophysiology of psoriasis in HIV. The main therapy of psoriasis with HIV is ARV. HIV can induce or as a risk factor of psoriasis. It's important to do a search further for risk factors in sexually transmitted diseases in patients with severe and recalcitrant psoriasis. The main therapy of psoriasis with HIV is ARV.
References
1. Alpalhão, Miguel, Borges-Costa, J.; Filipe, Paulo Psoriasis in HIV infection: an update. Int J STD AIDS. 2019;30(6):596-604.
2. Yen YF, Jen IA, Chen M, Lan YC, Lee CY, Chuang PH, Lee Y. HIV Infection Increases the Risk of Incident Psoriasis: A Nationwide Population-Based Cohort Study in Taiwan. J Acquir Immune Defic Syndr. 2017;75(5):493-9.
3. Lopes J, Almeida F. Psoriasis as a manifestation of an undiagnosed HIV infection. Case report. Galicia Clin. 2018; 79(1):32.
4. Kamiya, Koji & Kishimoto, Megumi & Sugai, Junichi & Komine, Mayumi & Ohtsuki, Mamitaro. Risk Factors for the Development of Psoriasis. Int J Mol Sci. 2019;20(18):4347.
5. Wolbers M, Babiker A, Sabin C, Young J, Dorrucci M, Chêne G, Collaboration Members. Pretreatment CD4 cell slope and progression to AIDS or death in HIV-infected patients initiating antiretroviral therapy-the CASCADE collaboration: a collaboration of 23 cohort studies. PLoS Med. 2010;7(2):e1000239.
6. Fink, D. L., Hedley, L., & Miller, R. F. Systematic review of the efficacy and safety of biological therapy for inflammatory conditions in HIV-infected individuals. Int J STD AIDS. 2017;28(2):110–19.
7. Nakamura M, Abrouk M, Farahnik B, Zhu TH, Bhutani T. Psoriasis treatment in HIV-positive patients: a systematic review of systemic immunosuppressive therapies. Cutis. 2018;101(1):38;42;56.
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