Complicating factors in the management of condyloma acuminata in HIV patients

Abstract

Condyloma Acuminata (CA) is an infectious disease with clinical manifestation of vegetation/ hyperkeratotic growth in the mucosal area and anogenital skin. More than 90% of CA cases are caused by infection of Human Papilloma Virus (HPV) type 6 or 11. Management of CA includes surgical and non-surgical therapy. However, the conventional therapy for CA have high recurrence rate, which ranges from 50-60%. Immunocompromised patients, including people with Human Immunodeficiency Virus (HIV) have higher recurrency rates compare to healthy people. Other matter arising in the management of CA in HIV patients is its resistance to conventional therapy. Success rate of CA therapy in HIV patients is related to the patient's immune response, low zinc levels in blood and also their CD4 levels.