Sign of Leser-Trelat: a paraneoplastic sign of internal malignancy

Abstract

A 63-year-old female presented with dark brown hyperpigmented macules and slightly elevated papules all over body, clinically and histopathologically suggestive of seborrhoeic keratosis. She was diagnosed as breast carcinoma 5 years back and got mastectomy done 2 years back. Cutaneous lesions appeared 6 months before the diagnosis of breast carcinoma and remained static after mastectomy, thus fulfilling some of the Curth’s criteria for the diagnosis of paraneoplastic syndrome. Till date there is only one report of Leser-Trelat sign with associated carcinoma of breast. We are reporting Leser-Trelat as a paraneoplastic phenomenon secondary to invasive ductal breast carcinoma for its rarity and the classical clinicopathological evidence.