Sign of Leser-Trelat: a paraneoplastic sign of internal malignancy

Authors

  • S.V. Choudhary Department of Dermatology, Venereology and Leprosy, JNMC, Sawangi, Wardha (Maharashtra), India
  • S. A. Bhattar Department of Dermatology, Venereology and Leprosy, JNMC, Sawangi, Wardha (Maharashtra), India
  • A.L. Singh Department of Dermatology, Venereology and Leprosy, JNMC, Sawangi, Wardha (Maharashtra), India

DOI:

https://doi.org/10.66344/jpad.v26i1.78

Keywords:

Seborrhoeic keratosis, breast carcinoma

Abstract

A 63-year-old female presented with dark brown hyperpigmented macules and slightly elevated papules all over body, clinically and histopathologically suggestive of seborrhoeic keratosis. She was diagnosed as breast carcinoma 5 years back and got mastectomy done 2 years back. Cutaneous lesions appeared 6 months before the diagnosis of breast carcinoma and remained static after mastectomy, thus fulfilling some of the Curth’s criteria for the diagnosis of paraneoplastic syndrome. Till date there is only one report of Leser-Trelat sign with associated carcinoma of breast. We are reporting Leser-Trelat as a paraneoplastic phenomenon secondary to invasive ductal breast carcinoma for its rarity and the classical clinicopathological evidence.

References

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2. Scarisbrick JJ, Woolford AJ, Russell-Jones R, Whittaker SJ. Loss of heterozygosity on 10q and microsatellite instability in advanced stages of primary cutaneous T-cell lymphoma and possible association with homozygous deletion of PTEN. Blood. 2000;95:2937-42.

3. Lynch HT, Fusaro RM, Pester JA, Lynch JF. Leser-Trelat sign in mother and daughter with breast cancer. J Med Genet. 1982;19:218-21.

4. Lee CH, Clark AR, Thorpe ME et al. Bile duct adenocarcinoma with Leser-Trelat sign and pure red blood cell aplasia. Cancer. 1980;46:1657-60.

Published

18.11.2016

Issue

Section

Case Reports

How to Cite

1.
Sign of Leser-Trelat: a paraneoplastic sign of internal malignancy. J Pak Assoc Dermatol [Internet]. 2016 Nov. 18 [cited 2026 Jul. 31];26(1):69-71. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/78