Papillon-Lefèvre Syndrome. All about palms, soles and gums: a brief review
DOI:
https://doi.org/10.66344/jpad.14.1.2004.773Abstract
Papillon-Lefèvre syndrome (PLS) is an autosomal recessive disorder of keratinization
characterized by palmoplantar keratoderma and periodontitis with subsequent loss of
teeth. The exact etiology of the diseases remains to be unraveled. Nonetheless
cathepsin C gene mutations may be involved. The present review focuses on the recent
advances about role of cathepsin C gene in the causation of PLS and other disorders.
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