Papillon-Lefèvre Syndrome. All about palms, soles and gums: a brief review
Abstract
Papillon-Lefèvre syndrome (PLS) is an autosomal recessive disorder of keratinizationcharacterized by palmoplantar keratoderma and periodontitis with subsequent loss ofteeth. The exact etiology of the diseases remains to be unraveled. Nonethelesscathepsin C gene mutations may be involved. The present review focuses on the recentadvances about role of cathepsin C gene in the causation of PLS and other disorders.References
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