Digital gangrene due to dopamine infusion- a case report
DOI:
https://doi.org/10.66344/jpad.v15i2.639Keywords:
Dopamine, gangrene, ischemia, shockAbstract
Dopamine is a vasopressor agent for the treatment of shock and hypotension in patients who
do not respond to plasma volume expansion. Use of dopamine is associated with severe
peripheral ischemia, particularly in patients in whom the peripheral circulation is already
impaired. We describe a case of digital gangrene due to intravenous dopamine infusion in a
45-year-old man who did not have any predisposing factor. The patient developed digital
gangrene within 24 hours of starting intravenous dopamine. Dopamine is one of the
commonly used vasopressor agents in the treatment of shock and hypotension and measures
should be taken to detect the possibility of the development of gangrene based on the
predisposing factor and if gangrene occurs, immediate steps should be taken for management
of the reaction.
References
McEvoy GK, Miller J, Litvak K et al.,
eds. AHFS Drug Information. New
York: American Society of Health-
System Pharmacists; 2003.
Park JY, Kanzler M, Swetter SM.
Dopamine-associated symmetric
peripheral gangrene. Arch Dermatol
; 133: 247-9.
Sweetman SC, ed. Martindale The
Complete Drug Reference, 33rd edition.
London: Pharmaceutical Press; 2002.
Dukes MNG, Aronson JK, ed. Meyler’s
Side Effects of Drugs, 14th edition.
Amsterdam: Elsevier; 2000.
Gibbs NM, Oh TE. Nitroglycerine
ointment for dopamine induced
peripheral digital ischemia. Lancet
; 2: 290.
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Copyright (c) 2016 M.M. Prabhu, S.M. Prabhu, P. Mishra, S. Palaian

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