Adult cutaneous Langerhans’ cell histiocytosis: a rare presentation, successful treatment with thalidomide

Authors

  • P.L. Chandravathi Department of Dermatology, Venereology and Leprosy, Care Institute of Medical Sciences, Hyderabad, Telangana, India
  • Praneet Awake Department of Dermatology, Venereology and Leprosy, Care Institute of Medical Sciences, Hyderabad, Telangana, India
  • Anil Fonseca Department of Pathology, Care Institute of Medical Sciences, Hyderabad, Telangana, India

DOI:

https://doi.org/10.66344/jpad.v26i2.57

Keywords:

cutaneous, adult, thalidomide, Langerhans’ cell histiocytosis

Abstract

Langerhans’ cell histiocytosis (LCH) is a rare clonal disorder of proliferating histiocytic cells expressing phenotypic markers of the epidermal Langerhans’ cells. LCH generally affects children. Adult LCH with single system disease limited to skin is uncommon and difficult to diagnose. The management of LCH is difficult as these disorders respond inconsistently to immunosuppressive and chemotherapeutic strategies. We report a case of 48 year female, diabetic and hypertensive presented as single system LCH limited to skin with history of recurrent painful erythematous ulcerated lesions in right axilla and both groins since 4 years with and limiting mobility of limbs. She was successfully treated with thalidomide. Thalidomide monotherapy represents an effective, safe and well-tolerated treatment option that should be considered as first-line therapy for single system LCH limited to skin which is rare and difficult to treat.

References

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Published

17.11.2016

Issue

Vol. 26 No. 2 (2016): April - June

Section

Case Reports

License

Copyright (c) 2016 P.L. Chandravathi, Praneet Awake, Anil Fonseca

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How to Cite

1.
Adult cutaneous Langerhans’ cell histiocytosis: a rare presentation, successful treatment with thalidomide. J Pak Assoc Dermatol [Internet]. 2016 Nov. 17 [cited 2026 Jul. 26];26(2):143-6. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/57