Comparison between efficacy of serial glycolic acid peel and triple combination cream vs. triple combination cream alone in treatment of melasma

Authors

  • Koukab Gulzar
  • Ghulam Mujtaba
  • Shahid Hameed

Keywords:

Glycolic acid, triple combination cream, melasma, hyperpigmentation

Abstract

Background Melasma is a common disorder of facial hyperpigmentation among Asian women. Many modalities of treatment are available but none is satisfactory.Objective To determine if serial glycolic acid peels provide additional improvement when combined with a time-tested triple combination cream (0.05% tretinoin, 4.0% hydroquinone, and 0.01% fluocinolone acetonide).Patients and methods Eighty melasma patients were divided into two groups of 40 each. One group received serial glycolic acid peels combined with a topical triple combination cream. The other, a control group, received only triple combination cream. The results were evaluated both subjectively (decrease in size and pigmentation) and with photographs taken at baseline, 4, 8 and 12 weeks (2 weeks after the sixth peel).Results A significant improvement from baseline to 12 weeks was observed in both groups (P<0.001). The group receiving the glycolic acid peels showed a trend toward more rapid and greater improvement, with statistically significant results (p<0.001). Only a few side effects were observed in the peel group.Conclusion This study demonstrates that serial glycolic acid peels provide an additional effect to a topical regimen for treating melasma if used judiciously and under supervision. 

References

Grimes PE. Melasma: etiology and therapeutic consideration. Arch Dermatol 1995; 131: 1453-7.

Perez M, Sanchez JL, Aguilo F. Endocrinologic profile of patients with idiopathic melasma. J Invest Dermatol 1983; 81: 543-5.

Resnik S. Melasma induced by oral contraceptive drugs. JAMA 1967; 199: 95-9.

Victor FC, Gelber J, Rao B. Melasma: a review. J Cutan Med Surg 2004; 8: 97-102.

Weismann K, Lorentzen HF. Dermoscopic color perspective. Arch Dermatol 2006; 142: 1250.

Anderson RT, Rajagopalan R. Development and validation of quality of life instrument for cutaneous diseases. J Am Acad Dermatol 1997; 37: 41-50.

Finlay AY. Quality of life measurement in dermatology: a practical guide. Br J Dermatol 1997; 136: 305-14.

Rendon MI, Gaviria JI. Review of skin-lightening agents. Dermatol Surg 2005; 31: 886-9.

Gupta AK, Gover MD, Nour K et al. The treatment of melasma: A review of clinical trials. J Am Acad Dermatol 2006; 55: 1048-65.

Torok, Helen M. A comprehensive review of long term and short term treatment of melasma with triple combination cream. Am J Clin Dermatol 2006; 7: 223-30.

Sarkar R, Kaur C, Bhalla M et al. The combination of glycolic acid peel with a topical regimen in the treatment of melasma in dark skinned patients: A comparative study. Dermatol Surg 2002; 28: 828-32.

Javaheri SM, Handa S ** et al. Safety and efficacy of glycolic acid facial peel in Indian women with melasma. Int J Dermatol 2001; 40: 354-7.

Lim JTE, Tham SN. Glycolic acid peel in the treatment of melasma among Asian women. Dermatol Surg 2008; 23: 177-9.

Aamir S, Rashid T, Nabi H, Haroon TS. Superficial chemical peeling with glycolic acid in melasma. J Pak Assoc Dermatol 2005; 15: 130-5.

Erbil H, Sezer E, Taston B et al. Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma. J Dermatol 2006; 34: 25-30.

Grover C, Reddu BS. The therapeutic value of glycolic acid peels in dermatology. Indian J Dermatol Venereol Leprol 2003; 69: 148-50.

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Published

2016-12-21

How to Cite

1.
Gulzar K, Mujtaba G, Hameed S. Comparison between efficacy of serial glycolic acid peel and triple combination cream vs. triple combination cream alone in treatment of melasma. J Pak Assoc Dermatol [Internet]. 2016Dec.21 [cited 2024Nov.8];20(2):84-8. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/426

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