ANA-negative systemic lupus erythematosus with targetoid lesions: Rowell syndrome or just a rare presentation of lupus erythematosus

Authors

  • Anup Kumar Tiwary Department of Dermatology,Venereology & Leprosy, Rajendra Institute of Medical Sciences, Bariatu, Ranchi
  • Dharmendra Kumar Mishra Department of Dermatology,Venereology & Leprosy, Rajendra Institute of Medical Sciences, Bariatu, Ranchi

DOI:

https://doi.org/10.66344/jpad.26.3.2016.37

Keywords:

Lupus erythematosus, erythema multiforme, Rowell syndrome

Abstract

Rowell syndrome is usually diagnosed by the presence of erythema multiforme (EM)-like targetoid lesions in the patients of cutaneous or systemic lupus erythematosus (CLE/SLE) and characterized by specific serological or immunological profile like speckled antinuclear antibody (ANA) pattern, antibody against saline extract of human tissues (anti-SjT) and positive serum rheumatoid factor (RF). The absence of universally accepted criteria and their poor specificity usually make the diagnosis very difficult. Moreover in the light of histopathological revelation of dermal mucin deposition along with interface changes and necrotic basal keratinocytes in the absence of serum positivity for ANA antibody and RF, true existence of this syndrome is still doubtful. Here we report a case of ANA-negative SLE having targetoid lesions on distal extremities and histopathological evidence of both the disease i.e LE and EM.

Author Biographies

Anup Kumar Tiwary, Department of Dermatology,Venereology & Leprosy, Rajendra Institute of Medical Sciences, Bariatu, Ranchi

Department of Dermatology,Venereology & Leprosy

Dharmendra Kumar Mishra, Department of Dermatology,Venereology & Leprosy, Rajendra Institute of Medical Sciences, Bariatu, Ranchi

Department of Dermatology,Venereology & Leprosy

References

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Published

2017-03-29

How to Cite

1.
Tiwary AK, Mishra DK. ANA-negative systemic lupus erythematosus with targetoid lesions: Rowell syndrome or just a rare presentation of lupus erythematosus. J Pak Assoc Dermatol [Internet]. 2017Mar.29 [cited 2026Apr.21];26(3):269-72. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/37

Issue

Vol. 26 No. 3 (2016): July - September

Section

Case Reports

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