Knowledge, Attitude, and Practice regarding Glutathione Whitening Treatment among the general population in a cosmopolitan city of Pakistan
DOI:
https://doi.org/10.66344/jpad.v36i2.3413Keywords:
Glutathione Whitening treatment, Skin tone, Skin lightening, Knowledge, AwarenessAbstract
Background Glutathione (GSH) Whitening Treatment has recently gained popularity as a cosmetic intervention to attain fairer skin tones. It is being used widely, especially, in urban areas where aesthetics clinics are administrating intravenous GSH as whole body whitening therapy.
Objective The objective of this study is to determine the knowledge, attitude, and practice regarding the use of glutathione in Lahore, Pakistan.
Methods A cross-sectional study was carried out among 353 people of various age groups. A validated questionnaire was used to collect data using online Google platform. Data was analyzed on SPSS version 25, the categorical data was presented through frequency and percentages.
Results Among the 353 respondents, 44.5% (157) were aged 20 years or below while 42.5% (150) were between the ages of 21 and 30 years. 57.5% (203) were females and 36.9% (130) had a medium skin tone. 71.4% (252) of the respondents were familiar with the idea of GSH mainly through social media (59.9%; 151) or family and friends (53.2%; 134). Only 34.3% (121) had used GSH for skin lightening, most commonly in injectable form (83; 68.6%). Female gender and dark skin tone was significantly associated with use of GSH for skin lightening.
Conclusion Individuals with a dark skin and female gender were more likely to use GSH. However, more research is needed on the psychosocial factors driving GSH use. GSH-related social media content should be better monitored by the authorities and public health campaigns should encourage inclusive and healthier beauty standards.
References
1. Pollock S, Taylor S, Oyerinde O, Nurmohamed S, Dlova N, Sarkar R, et al. The dark side of skin lightening: An international collaboration and review of a public health issue affecting dermatology. Int J Women's Dermatol. 2021 Mar 1;7(2):158-64. Doi: https://doi.org/10.1016/j.ijwd.2020.09.006
2. Peltzer K, Pengpid S, James C. The globalization of whitening: prevalence of skin lighteners (or bleachers) use and its social correlates among university students in 26 countries. Int J Dermatol. 2016 Feb;55(2):165-72.
DOI: https://doi.org/10.1111/ijd.12860
3. Alzahrani TF, Alotaibi SM, Alzahrani AA, Alzahrani AF, Alturki LE, Alshammari MM, et al. Exploring the Safety and Efficacy of Glutathione Supplementation for Skin Lightening: A Narrative Review. Cureus. 2025 Jan 27;17(1): e78045.
DOI: http://doi.org/10.7759/ cureus.78045
4. Mahmood M. The effectiveness of glutathione on skin lightening: a review. Int J Med Sci. 2022 May 14;5(2):5-16.
DOI: http://doi.org/10.32441.ijms.5.2.2
5. Bamerdah S, Alhothali OS, Aldajani BM, Alghanemi L, Mleeh NT. A cross-sectional study of the knowledge, practice, and attitude towards skin-lightening products among the general population in the western region of Saudi Arabia. Cureus. 2023 Jan 22;15(1):e34069. DOI: https://doi.org/10.7759/cureus.34069
6. Sayed S, Sayed AE, Amin MHJ, Suliman WY, Eltahir HB. Knowledge Attitude and Practice of Skin Whitening Products among Students in Ahfad University for Women. Int J Clin Med Edu Res. 2024;3(1):1-6. Available from https://www.opastpublishers.com/open-access-articles/knowledge-attitude-and-practice-of-skin-whitening-products-among-students-in-ahfad-university-for-women.pdf
7. Amodu MO. Knowledge, attitude and practice of skin whitening among female university students in Northeastern Nigeria. Open Access Lib J. 2018;5(04):1. DOI: https://doi.org/10.4236/oalib.1104501
8. Tesfamariam S, Bahta M, Weldemariam DG, Tesfamariam EH, Yemane H, Bahta I, Russom M. Awareness, perception, and utilization of skin lightening agents among females of Asmara, Eritrea: a cross-sectional study. Clin Cosmet Investig Dermatol. 2023 Dec 31:1191-202. DOI: https://doi.org/10.2147/CCID.S396686
9. Asif M, Riaz MR, Shadab H, Khan A, Hassan A, Iqbal S. Prevalence of Skin Lightening Product Usage among the Young Generation in Lahore after Puberty: A Comprehensive Study. Saudi J Med. 2024;9(1):1-6.
DOI: doi.org/10.36348/sjm.2024.v09i01.001
10. Noreen N, Perveen R. Skin Lightning Practices Among Women Living in Lahore; Its Prevalence, Effects, Determinants and Awareness. J Biol All Health Sci. 2025 Mar 14;5(1):97-102. DOI: https://doi.org/10.56536/jbahs.v5i1.120
11. Wudiri ZW, Bolori MT, Bukar FL, Oloyede T, Amodu MO, Abulfathi AA, et al. Knowledge, Perception and Practice of Skin Bleaching among Adults in Northeastern Nigeria. Open Acces Lib J. 2024 May 9;11(5):1-26. DOI: https://doi.org/10.4236/oalib.1111390
12. Yayehrad AT, Lule A, Tebabal AT, Esmael M, Risqey N, Temesgen S, Negash S, Hamid S, Tasew S, Mekonen S, Siraj EA. Concern on skin lightening product safety: Level of awareness and associated factors among female users in Bahir Dar City, Ethiopia. Clin Cosmet Investig Dermatol. 2023 Dec 31:1753-61. DOI: https://doi.org/10.2147/CCID.S416460
13. Al Kathiri MA. Knowledge, Attitude, and Practices on the Use of Bleaching Agents Among Students in the University, Al Dakhliya Governorate, Sultanate of Oman. Res J. 2022 June;297(E):139-44. Available from https://www.researchgate.net/profile/Jiji-Joseph/publication/375450451
14. Sagoe D, Pallesen S, Dlova NC, Lartey M, Ezzedine K, Dadzie O. The global prevalence and correlates of skin bleaching: a meta‐analysis and meta‐regression analysis. Int J Dermatol. 2019 Jan ;58(1):24-44. DOI: https://doi.org/10.1111/ijd.14052
15. Jagadeesan S, Kaliyadan F, Ashique KT, Karunakaran A. Bleaching and skin-lightening practice among female students in South India: a cross-sectional survey. J Cosmet Dermatol. 2021;20(4):1176-81 DOI: https://doi.org/10.1111/jocd.13689
16. Khalil RA. Knowledge, Attitude and Practice of Skin Whitening Products, Among Sudanese Undergraduate Females, 2021. Research Square. 2022:1-17. DOI:https://doi.org/10.21203/rs.3.rs-1221251/v1
17. Egbi OG, Kasia B. Prevalence, determinants and perception of use of skin lightening products among female medical undergraduates in Nigeria. Skin Health Dis. 2021 Sep;1(3):ski2-46. DOI: https://doi.org/10.1002/ski2.46
18. Okoro E, Barminas R, Olarinoye G, Magaji D, Umar O. Knowledge, attitude and practice of skin bleaching among adoleescents in Keffi, North-central Nigeria. Nig J Dermatol. 2022 Dec 30;12(2).37-45 Available from https://nigjdermatology.com/index.php/NJD/article/view/189
19. Badulla WF, Alshakka M, Ibrahim MI. Reported Side-Effects of Using Skin-Lightening Products in Aden-Yemen: Knowledge, Attitude and Practice. J Pharm Res Int. 2022;34(53A):31-41. DOI: https://doi.org/10.9734/JPRI/2022/v34i53A7225
20. Nyoni-Kachambwa P, Naravage W, James NF, Van der Putten M. A preliminary study of skin bleaching and factors associated with skin bleaching among women living in Zimbabwe. Afri Health Sci. 2021;21(1):132-9.
DOI:https://dx.doi.org/10.4314/ahs.v21i1.18
21. Ayyash M, Jaber K, Nassar RI, Fino L, Mango L, Abuodeh A. Skin-lightening products and Jordanian women: Beliefs and practice. A cross-sectional study. PloS One. 2023 Nov 21;18(11):e0293896.
DOI:https://doi.org/10.1371/journal.pone.0293896
22. Beshir S, Al-Gailani ES, Ramadan D, Bassam G, Maher E, Ismail S, et al. Women’s knowledge, perception, practice, and experience of using of skin-lightening products in the United Arab Emirates (UAE): A cross-sectional survey. J Public Health Res. 2023 Oct;12(4): 22799036231204356. DOI:https://doi.org/10.1177/22799036231204356
23. Alrayyes SF, Alrayyes SF, Farooq UD. Skin-lightening patterns among female students: a cross-sectional study in Saudi Arabia. Int J Womens Dermatol. 2019 Sep 1;5(4):246-50. DOI: https://doi.org/10.1016/j.ijwd.2019.04.026
24. Bakare OQ, Oluwole EO, Anyanwu-Iyah EH, Aworinde OG, Lawal EO. Skin lightening: knowledge, attitude, practices and the motivations for its use among the residents of Ikeja local government area, Lagos. Ann Health Res. 2023 Mar 26;9(1):1-1. DOI: https://doi.org/10.30442/ahr.0901-01-185
25. Banala M, Mamidipaka A, Ogunleye T. Skin-lightening product use among south asian americans: Cross-sectional survey study. JMIR Dermatol. 2023 Nov 2;6(1):e49068. DOI: https://doi.org/10.2196/49068
26. Zubair S, Hafeez S, Mujtaba G. Efficacy of intravenous glutathione vs. placebo for skin tone lightening. J Pak Assoc Dermatol. 2016;26(3):177-81. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/18.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Journal of Pakistan Association of Dermatologists

This work is licensed under a Creative Commons Attribution 4.0 International License.
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.


