The Effect of Mango Leaf Extract Cream (Mangifera indica L. var. kelong) 3% on Facial Skin Aging Based on Dermoscopic and Skin Characteristic Analysis
DOI:
https://doi.org/10.66344/jpad.v36i2.3238Keywords:
skin aging, mango leaf, Mangifera indica L. var. kelongAbstract
Background The progressive aging of the skin is a multi-faceted and intricate process. The anti-elastase, anti-collagenase, anti-hyaluronidase, and anti-tyrosinase properties of the polyphenols found in mango leaves, especially mangiferin, contribute to the improvement of the look of aged skin.
Objective We aimed to evaluate the effects of a 3% mango leaf extract cream (Mangifera indica L. var. kelong) on facial skin aging.
Methods Forty participants showing signs of facial aging were enrolled in study using pre and post test design without a control group, as this study was intended as a preliminary evaluation of the effects of Mangifera indica extract. Detailed medical history and clinical evaluation were done by using skin analyzer and dermoscope using the dermoscopic photoaging scale (DPAS) before and after administering 3% mango leaf extract cream. At the end of study side effects and degree of satisfaction were also recorded.
Results After 8 weeks, individuals experiencing facial skin aging had a significantly lower DPAS score. According to the skin analyzer, there were significant differences in spot evaluation, roughness, and ultraviolet moisture, while wrinkles, ultraviolet damage, and ultraviolet pigmentation showed a decrease in the mean results, although the difference was not significant. None of the subjects had any side effects with mango leaf extract cream.
Conclusion Topical application of a 3% mango leaf extract cream effectively improves the appearance of aging facial skin, as demonstrated by skin analyzer assessments showing enhanced spot appearance, reduced roughness, and improved ultraviolet moisture levels. The treatment was well tolerated, with no reported side effects and a high level of user satisfaction.
References
1. Muslim M, Jusuf NK, Putra IB. The dermoscopic features of facial aging among diverse ethnicity in Medan, Indonesia. Bali Med J. 2021;10(2): 904-9.
2. Cook MK, Kaszycki MA, Richardson I, Taylor SL, Feldman SR. Comparison of two devices for facial skin analysis. J Cosmet Dermatol. 2022;21:7001-6
3. Jusuf NK, Putra IB, Muslim M. Evaluation of dermoscopic photoaging score among multiethnic in Medan, Indonesia. Bali Med J. 2022;11(3):1919-23.
4. Minniti G, Laurindo LF, Machado NM, Duarte LG, Guiguer EL, Araujo AC, et al. Mangifera indica L; by-products, and mangiferin on cardio-metabolic and other health conditions: A systematic review. Life. 2023;13(12):2270.
doi:10.3390/life13122270.
5. El-Nashar HAS, El-labbad EM, Al-Azzawi MA, Ashmawy NS. A New Xanthone Glycoside from Mangifera indica L.: Physicochemical Properties and In Vitro Anti-Skin Aging Activities. Molecules. 2022;27:2609.
6. Wong QYA, Chew FT. Defining skin aging and its risk factors: a systematic review and meta-analysis. Sci Rep. 2021 Nov 11;11(1):22075.
7. Milani M, Colombo F. Skin Anti-Aging Effect of Oral Vitamin A Supplementation in Combination with Topical Retinoic Acid Treatment in Comparison with Topical Treatment Alone: A Randomized, Prospective, Assessor-Blinded, Parallel Trial. Cosmetics. 2023;10(5):144.
8. Griffiths TW, Watson REB, Langton AB. Skin ageing and topical rejuvenation strategies. Br J Dermatol. 2023;1889(1):i17–i23.
9. El-Nashar HAS, Mostafa NM, Eldahshan OA, Singab ANB. A new antidiabetic and anti-inflammatory biflavonoid from Schinus polygama (cav.) cabrera leaves. Nat Prod Res. 2022;36:1182-90.
10. Kumar M, Saurabh V, Tomar M, Hasan M, Changan S, Sasi M, et al. Mango (Mangifera indica L.) Leaves: Nutritional Composition, Phytochemical Profile, and Health-Promoting Bioactivities. Antioxidants. 2021;10:299.
11. Sferrazzo G, Palmeri R, Restuccia C, Parafati L, Siracusa L, Spampinato M, et al. Mangifera indica L. Leaves as a Potential Food Source of Phenolic Compounds with Biological Activity. Antioxidants. 2022;11:1313.
12. Sirirungsee V, Samutrtai P, Sangthong P, Papan P, Leelapornpisid P, Saenjum C, et al. Electrosprayed Nanoparticles Containing Mangiferin-Rich Extract from Mango Leaves for Cosmeceutical Application. Nanomaterials. 2023;13:2931.
13. Damayanti DA. Antioxidant activity and photoprotective effects of ethanol extract of Gedong mango leaves (Mangifera indica L. var. Gedong) [thesis]. Purwokerto: Universitas Muhammadiyah Purwokerto; 2020. Available from: https://repository.ump.ac.id/10064.
14. García-Villegas A, Fernández-Ochoa Á, Rojas-García A, Alañón ME, Arráez-Román D, Cádiz-Gurrea, MDLL et al. The Potential of Mangifera indica L. Peel Extract to Be Revalued in Cosmetic Applications. Antioxidants. 2023;12: 1892.
15. Chomchoei N, Leelapornpisid P, Tipduangta P, Sangthong P, Papan P, Sirithunyalug B, Samutrtai P. Potential of electro-sprayed purified mangiferin nanoparticles for anti-aging cosmetic applications. RSC Adv. 2023 Dec 1;13(50):34987-35002.
16. Khan ZU, Khan T, Mannan A, Ali A, Ni J. In Vitro and Ex Vivo Evaluation of Mangifera indica L. Extract-Loaded Green Nanoparticles in Topical Emulsion against Oxidative Stress and Aging. Biomedicines. 2022;10:2266.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Journal of Pakistan Association of Dermatologists

This work is licensed under a Creative Commons Attribution 4.0 International License.
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.


