Guttate psoriasis induced by Staphylococcus aureus infection
DOI:
https://doi.org/10.66344/jpad.v36i1.3095Keywords:
Guttate psoriasis, staphylococcus aureusAbstract
Guttate psoriasis (GP) is an acute form of psoriasis commonly triggered by streptococcal infection, particularly in the pharyngeal or perianal regions. Its etiology involves both environmental and genetic factors that contribute to a complex immune response in the skin. Genetic predisposition, environmental factors, and immune dysfunction all contribute to the pathogenesis of psoriasis with host-microbe interaction governing the progression of this disease. Emerging evidence has indicated that infection is an environmental trigger for psoriasis and plays multiple roles in its maintenance as evidenced by the frequent association between guttate psoriasis onset and acute staphylococcal infection. Different infectious factors act on immune cells to produce inflammatory cytokines that can induce or aggravate psoriasis. We reported a 57-year-old female patient presented with erythematous plaques. The throat swab examination revealed aerobic Staphylococcus aureus growthReferences
Goh C, Cheng C, Agak G, Zanglein AL, Graber EM, Thiboutot DM, Kim J. Acne vulgaris. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer JS, editors. Fitzpatrick’s Dermatology in General Medicine. 9th ed. New York: McGraw-Hill Companies; 2019. p.1391–1412.
Zhou S, Yao Z. Roles of infection in psoriasis. Int J Mol Sci. 2022;23(12):6995. doi:10.3390/ijms23126995.
Zhou T, Koussiouris J, Kim L, Vender R. Management of guttate psoriasis: a systematic review. J Cutan Med Surg. 2024;28(6):577–84. doi:10.1177/12034754241266187.
Prameswari FU, Prakoeswa CRS, Ferriastuti W. Narrowband ultraviolet B (NB-UVB) phototherapy in psoriasis: a retrospective study. Berkala Ilmu Kesehatan Kulit dan Kelamin. 2022;34(2):99–108. doi:10.20473/bikk.v34i2.2022.99–108.
Fernandez-Figueras MT, Puig L. Histopathological diagnosis of psoriasis and psoriasiform dermatitides. Diagn Histopathol. 2025;31(2):87–97. doi:10.1016/j.mpdhp.2024.11.005
Miao M, Yan J, Sun Y, Liu J, Guo S. Psoriasis: unraveling disease mechanisms and advancing pharmacological and nanotechnological treatments. J Inflamm Res. 2025;18:2045–72. doi:10.2147/jir.s506103.
Rizzetto G, Molinelli E, Radi G, Cirioni O, Brescini L, Giacometti A, et al. MRSA and skin infections in psoriatic patients: therapeutic options and new perspectives. Antibiotics (Basel). 2022;11(11):1504.
doi:10.3390/antibiotics11111504
Cho M, Yang J, Jung WH, Kim HS. A case of Staphylococcus simulans colonization in a patient with psoriasis. J Mycol Infect. 2024;29(1):7–10. doi:10.17966/JMI.2024.29.1.7
Sitton B, Walker T, Mital R, Varra V, Kaffenberger J. Antistreptococcal treatment of psoriasis: a systematic review. Arch Dermatol Res. 2024 Jun 8;316(7):363.
doi:10.1007/s00403-024-03051-8.
Miura S, Igarashi A, Okazaki H, et al. Staphylococcus aureus and Streptococcus pyogenes induce psoriasis-related transcriptomes augmented by IL-17A and TNF-α. J Invest Dermatol. 2023;143(8):1613–7.e5.
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