Clinical audit on monitoring of clinical and laboratory parameters in patient of acne taking oral isotretinoin

Authors

  • Rutaba Kiran Department of Dermatology, King Edward Medical University, Mayo Hospital Lahore.
  • Zareen Saqib Suleri Department of Dermatology, Khawaja Mohammad Safdar Medical College, Allama Iqbal Memorial Teaching Hoaspital, Sialkot
  • Sohaib Haider Department of Endocrinology, Services Institute of Medical Sciences, Services Hospital Lahore
  • Sadia Jabeen Department of Dermatology, King Edward Medical University, Mayo Hospital Lahore
  • Raffad Department of Medicine, Services Institute of Medical Sciences, Services Hospital Lahore
  • Atiya Arshad Department of Dermatology, King Edward Medical University, Mayo Hospital Lahore.
  • Shahbaz Aman Department of Dermatology, King Edward Medical University, Mayo Hospital Lahore

Keywords:

Clinical audit, Acne, Isotretinoin

Abstract

Objective The aims of this study were to evaluate whether oral retinoids (isotretinoin) prescription in female patients of acne is following standard guidelines/ set protocol or not.   Methods This clinical audit involved 50 female patients of child bearing age, with acne taking oral isotretinoin, who presented in the outpatient department of Mayo hospital Lahore. Patients were diagnosed clinically by the presence of open and closed comedones, papules, pustules, nodules involving the seborrhoeic sites. An informed consent was taken after which they were asked the relevant questions from the questionnaire. The standard was that 100% of patients should be counseled about the key three components (1) Liver function tests and fasting lipid profile monitoring at baseline, (2) Counseling for contraception and (3) Counseling for depressive symptoms.   Results Out of 50 patients enrolled in our study, all (100%) were females, mean age being 23.32. 49 (98%) of our patients were being counseled for contraception, while in 37 (70%) of the patients, routine monitoring for liver function tests and fasting lipid profile was being carried out. 15 (37%) of our patients were being counseled for depressive symptoms.   Conclusion Prescribing oral isotretinoin requires certain prerequisites that are being fulfilled. However, more focused perspective should be followed in this regard.  

Author Biography

Raffad, Department of Medicine, Services Institute of Medical Sciences, Services Hospital Lahore

Professor

References

Alshammrie F F, Alshammari R, Alharbi R M,Khan FH, Alshammari S K. Epidemiology of Acne Vulgaris and Its Association With Lifestyle Among Adolescents and Young Adults in Hail, Kingdom of Saudi Arabia: A Community- Based Study: Cureus.2020;12:9277.

Eichenfield D Z, Sprague J,Eichenfield L F.Management of acne vulgaris: JAMA. 2021;326: 2055-2067.

Zaenglein A l, Pathy A , Schlosser B J, Khan A A, Baldwin H E, Berson D S et al. Guidelines of care for the management of acne vulgaris: J Am Acad Dermatol.2016;74:945-73.

Aung D T. Oral retinoids: DermNet NZ . June 2020.

Dilnawaz M, Mazhar H, Shaikh Z I. Clinical audit: A simplified approach: J Pak Assoc Dermatol.2012;22 :358-362.

Alshehri AA, Althobaiti BA, Khawagi WY, Murphy KD. Awareness of isotretinoin use and safety in Saudi Arabia: A nationwide cross-sectional study: Saudi Pharm J.2023;31:11.

Ibrahim A A M, Alshatri A A , Alsuwaidan S, Almutairi L, Aljasser N, Mahmoud M A et al. Awareness of isotretinoin use and Saudi FDA pregnancy prevention program in Riyadh, Saudi Arabia: A cross-sectional study among female patients saudi pharma J:2021 ; 29: 527-532.

Zomerdiijk I M, Ruiter R, Houweling L M A, Herings R M C, Sturkenboom M C J M, Straus S M J M et al. Isotretinoin exposure during pregnancy: a population-based study in The Netherlands: BMJ open.2014;4:11.

Ludwig RJ, Kridin K. Isotretinoin and the risk of psychiatric disturbances: A global study shedding new light on a debatable story : J Am Acad Dermatol. 2023; 88:388-394.

M.J.D. Goodfield, N.H. Cox, A. Bowser, J.C. McMillan, L.G. Millard, N.B. Simpson, A.D. Ormerod, Advice on the safe introduction and continued use of isotretinoin in acne in the U.K: British Journal of Dermatology.2010; 162: 1172-1179.

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Published

2024-05-06

How to Cite

1.
Kiran R, Suleri ZS, Haider S, Jabeen S, Raffad, Arshad A, Aman S. Clinical audit on monitoring of clinical and laboratory parameters in patient of acne taking oral isotretinoin. J Pak Assoc Dermatol [Internet]. 2024May6 [cited 2024Nov.3];34(1):106-10. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/2747

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