Metastatic testicular cancer in a patient with arsenical keratosis

Authors

  • Satyendra Kumar Singh
  • Farzeen Nasir
  • Tulika Rai

Keywords:

Arsenic, testicular cancer, punctate keratoses

Abstract

Arsenicosis is a multisystem disorder, with many cutaneous features. The cutaneous manifestations take the form of pigmentary changes, hyperkeratosis, and skin cancers (Bowen's disease, squamous cell carcinoma, and basal cell carcinoma). It is a known carcinogen and there is association between chronic arsenic exposure and malignancy of bladder, lung, liver, kidney and other visceral malignancies. Our patient came from an endemic area where levels of arsenic are high in drinking water and had features of arsenical keratosis for past fifteen years along with metastatic testicular cancer at the time of presentation. Arsenic exposure may increase the risk of testicular cancer. 

References

Zaldivar R. Arsenic contamination of drinking water and foodstuff causing endemic chronic poisoning. Beitr Pathol. 1974;151:384-400.

Arsenicosis. Case-Detection, Management and Surveillance. Report of a Regional Consultation. New Delhi: WHO Regional Office for South-East Asia; June 2003.

Saha KC, ed. Arsenicosis in West Bengal. 1st ed. Kolkata: Sadananda Prakashani; 2002. p. 11-52.

Khan MM, Sakauchi F, Sonoda T et al. Magnitude of arsenic toxicity in tube-well drinking water in Bangladesh and its adverse effects on human health including cancer: evidence from a review of the literature. Asian Pac J Cancer Prev. 2003;4:7-14.

Gomez-Caminero A, Howe P, Hughes M et al. Kinetics and metabolism in laboratory animals and human. Arsenic and arsenic compound. Environmental health criteria 224. International Programme on Chemical Safety. Geneva: World Health Organization; 2001. p. 112-67.

Tay CH. Cutaneous manifestations of arsenic poisoning due to certain Chinese herbal medicine. Australas J Dermatol. 1974;15:121-31.

Rossman TG, Wang ZL. Expression cloning for arsenite resistance resulted in isolation of tumor suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis. Carcinogenesis. 1999;20:311-6.

Ahmad Y. The largest mass poisoning in recorded history. Int Health. 2004;82:57-8.

Rosset M. Arsenical keratoses associated with carcinomas of internal organs. Cancer Med Assoc J. 1958;78:416-9.

DuMond JW Jr, Singh KP. Gene expression changes and induction of cell proliferation by chronic exposure to arsenic of mouse testicular Leydig cells. J Toxicol Environ Health A. 2007;70:1150-4.

Downloads

Published

2016-12-09

How to Cite

1.
Singh SK, Nasir F, Rai T. Metastatic testicular cancer in a patient with arsenical keratosis. J Pak Assoc Dermatol [Internet]. 2016Dec.9 [cited 2024Dec.7];23(1):96-8. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/270

Issue

Section

Case Reports

Similar Articles

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)

1 2 > >>