Chemical-induced vitiligo in a rubber gloves factory worker

Authors

  • Oky Fauzul Zakina Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Windy Keumala Budianti Allergy and Immunology Division, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia/ Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
  • Astri Mulyantini Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia/ Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
  • Dewi Soemarko Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

DOI:

https://doi.org/10.66344/jpad.34.4.2024.2664

Abstract

Chemical-induced vitiligo or chemical leukoderma, is an acquired skin depigmentation due to repeated exposure to specific chemical compounds in subjects with genetic susceptibility to vitiligo. Male patient with vitiligo who worked in a rubber gloves factory came to dermatology clinic. We analyze the relationship between his disease and his work. A 31-year-old man presented with a history of white plaque on the forehead, nose, right cheek bone and palpebra and behind both ears in the last 18 months. He reported no itchiness, redness, or pain. He works as a rubber gloves factory worker whose job is to carry and pour raw rubber gloves material such as potassium hydroxide and powdered premixed latex into the boiler for 3 years. The patient’s diagnosis of vitiligo was chemical-induced or aroused from occupational exposure, possibly the premixed latex. Further investigation is needed to find the composition of premixed latex to establish chemical-induced vitiligo as the occupational diagnosis.

References

Mazzei Weiss ME. Vitiligo: to biopsy or not to biopsy? Cutis. 2020;105(4):189-90.

Eleftheriadou V. Reliability and validity of the Vitiligo Signs of Activity Score. Br J Dermatol. 2020;183(5):801-2.

Bergqvist C, Ezzedine K. Vitiligo: A Review. Dermatology. 2020;236(6):571-92.

Ghosh S, Mukhopadhyay S. Chemical leucoderma: a clinico-aetiological study of 864 cases in the perspective of a developing country. Br J Dermatol. 2009;160(1):40-7.

Oliver EA, Schwartz L, Warren LH. Occupational leukoderma. J Am Med Assoc. 1939;113(10):927.

Taylor JS, Maibach HI, Fisher AA, Bergfeld WF. Contact leukoderma associated with the use of hair colors. Cutis. 1993;52(5):273-80.

Pandy RK, Kumar AS. Contact Leukoderma Due to ‘Bindi’ and Footwear. Dermatology. 1985;170(5):260-2.

Meier S, Andersen TC, Lind-Larsen K, Svardal A, Holmsen H. Effects of alkylphenols on glycerophospholipids and cholesterol in liver and brain from female Atlantic cod (Gadus morhua). Comp Biochem Physiol C Toxicol Pharmacol. 2007;145(3):420-30.

Kroll TM, Bommiasamy H, Boissy RE, Hernandez C, Nickoloff BJ, Mestril R, et al. 4-Tertiary Butyl Phenol Exposure Sensitizes Human Melanocytes to Dendritic Cell-Mediated Killing: Relevance to Vitiligo. J Invest Dermatol. 2005;124(4):798-806.

Mosher D, Fitizpatrick T. Chemical leukoderma. In: Sober A, Fitzpatrick T, editors. Yearbook of Dermatology. Bonston: Mosby; 1994. p. 3-13.

Miyamoto L, Taylor J. Chemical leukoderma. In: Hann S, Nordlund J, editors. A Comprehensive Monograph on Basic and Clinical Science. London: Blackwell Science; 2000. p. 269-80.

Glassman SJ. Vitiligo, reactive oxygen species and T-cells. Clin Sci (Lond). 2011;120(3):99-120.

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Published

2024-10-11

How to Cite

1.
Zakina OF, Budianti WK, Mulyantini A, Soemarko D. Chemical-induced vitiligo in a rubber gloves factory worker. J Pak Assoc Dermatol [Internet]. 2024Oct.11 [cited 2026Apr.12];34(4):1098-103. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/2664

Issue

Vol. 34 No. 4 (2024): October-December

Section

Case Reports

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