Efficacy of combination therapy with topical fixed dose adapalene 0.1% and benzoyl peroxide 2.5% plus doxycycline 200 mg oral versus oral isotretinoin for the treatment of moderate to severe acne vulgaris
Keywords:
Isotretinoin, Acne vulgaris, Adapalene, Benzoyl peroxide, DoxycyclineAbstract
Objective Comparison of efficacy of combination therapy with topical fixed dose adapalene0.1%/ benzoyl peroxide2.5% plus doxycycline 200 mg oral versus oral isotretinoin for the treatment of moderate to severe acne vulgaris. Methods The study was performed at dermatology section of Lady Reading Hospital Peshawar and a total of 160 patients participated in the study. They were allocated randomly into two groups by lottery method. Those in group A, were given topical fixed dose adapalene0.1%/ benzoyl peroxide2.5% plus oral doxycycline 200 mg and patients in group B received, oral isotretinoin 1 mg/kg/day. Patients were followed up at 12 weeks and response was noted in terms of more than 50% improvement from baseline in total acne burden. Results In Group A, 45 (56.3%) patients were male, while 35 (43.8%) were female. Similarly, in group B, 50 (62.5%) patients were male and 30 (37.5%) were female. In group A, the total number of lesions decreased from a mean of 76.53 to 23.86 and in group B from mean of 85.05 to a mean of 28.06. The efficacies showed by topical fixed dose adapalene0.1%/ benzoyl peroxide 2.5% plus doxycycline 200 mg and oral isotretinoin are 82.5% and 92.5%, respectively, having no significant difference. Conclusion Fixed dose preparation of adapalene 0.1%/benzoyl peroxide 2.5% gel in combination with oral doxycycline is equally effective to oral isotretinoin in the management of moderate to severe acne.References
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