Non langerhans cell histiocytoses in genitalia: A rare entity
Keywords:
Non-Langerhans cell, cyclophosphamide, immunohistochemistryAbstract
A 35 year old man presented with multiple reddish to skin colored scrotal swellings for the last 8 to 10 months. On biopsy, well circumscribed dense nodular infiltrate composed of histiocytes, lymphocytes and stray plasma cells. On IHC: CD 68 +ve, but CD1a, S100, Langerin, BRAFV600E, CD30 were negative. Based on HPE and IHC reports, a diagnosis of non-Langerhans cell histiocytosis was made. Initially the lesions were treated with intra-lesional corticosteroids, without any significant improvement. As a newer therapy, we tried oral cyclophosphamide 50 mg BD for 2 months, followed by 50 mg OD as maintenance dose, no new lesions were noted.References
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doi: 10.1016/j.jaad.2006.06.010. Epub 2006 Oct 9. PMID: 17097374.
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Published
2024-07-02
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1.
Chowdhury S, Das D, Sarkar P, Karmakar S, Nayak PS, Gharami RC. Non langerhans cell histiocytoses in genitalia: A rare entity. J Pak Assoc Dermatol [Internet]. 2024Jul.2 [cited 2024Dec.6];34(3):749-51. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/2581
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