The frequency of different types of squamous cell carcinoma according to their triggering factors in patients with dark complexion skin
Keywords:
Squamous cell carcinoma, Triggering factors, Sunlight exposure, ; Lichen planus, Old burn scarAbstract
Background Squamous cell carcinoma is not an uncommon type of non-melanoma skin cancer that could be induced by different triggering factors. The frequency of these different types of triggering factors is not well established in the dermatological literatures Objective To gather all patients with squamous cell carcinoma and try to classify them according to their triggering factors Patients and methods This is a cross-sectional study that was carried out during the period from 2014-2023 where all patients with squamous cell carcinoma were collected and analyzed into groups according to their triggering factors. Nearly all patients were Fitzpatrick skin type III and IV. Full demographic and clinical data were studied and evaluated. A histopathological assessment was done as a confirmatory measure. Results Full analysis and evaluation were carried out for 95 cases of squamous cell carcinoma and classified into the following groups: lower lip sunlight-induced SCC in 44(46.3%) cases, ordinary SCC without triggering factor in 22(23.1%), lichen planus induced SCC in 17(17.89%) and burn-induced in 12(12.63%) patients with SCC. Conclusion Cutaneous squamous cell carcinoma is not a common tumor but is frequently triggered by sunlight exposure, lichen planus and old burn scar.References
Rogers HW, Weinstock MA, Feldman SR, Coldiron BM. Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the US population, 2012. JAMA dermatology. 2015;151(10):1081-6.
Martincorena I, Campbell PJ. Somatic mutation in cancer and normal cells. Science. 2015;349(6255):1483-9.
Mahmood N, Rabbani SA. DNA methylation readers and cancer: mechanistic and therapeutic applications. Frontiers in oncology. 2019;9:489.
Love RL, Breidahl AF. Acute squamous cell carcinoma arising within a recent burn scar in a 14-year-old boy. Plastic and reconstructive surgery. 2000;106(5):1069-71.
Copcu E. Marjolin’s ulcer: a preventable complication of burns? Plastic and reconstructive surgery. 2009;124(1):156e-64e.
Kowal-Vern A, Criswell BK. Burn scar neoplasms: a literature review and statistical analysis. Burns. 2005;31(4):403-13.
Sharquie KE, Jabbar RI. The Frequency of Squamous Cell Carcinoma Among Patients with Long Standing Burn Scars. Journal of the Turkish Academy of Dermatology. 2021;15(3):65-9.
Wagner G, Rose C, Sachse MM. Clinical variants of lichen planus. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2013;11(4):309-19.
Sharquie KE, Noaimi AA, Al-Shukri MA. Melasma, Melasma-Like Lichen Planus Actinicus, and Butterfly Lichen Planus Actinicus Build up One Spectrum (Clinico-Histopathological Study). Journal of Cosmetics, Dermatological Sciences and Applications. 2015;5(03):212.
Sharquie KE, Hadi FO, Jabbar RI. All Variants of Lichen Planus are a Possible Triggering Factors for Squamous Cell Carcinoma. Asian Journal of Research in Dermatological Science. 2021;4(4):55-62.
Sharquie K, Al-Janabi W. Squamous cell carcinoma of lower lip: Topical podophyllin is an alternative therapy for early cases. Am J Dermatol Venereol. 2019;8(4):61-5.
Kraft S, Granter SR. Molecular pathology of skin neoplasms of the head and neck. Archives of Pathology and Laboratory Medicine. 2014;138(6):759-87.
Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA-ATLANTA-. 1999;49:33-64.
Filipowicz E, Adegboyega P, Sanchez R, Gatalica Z. Expression of CD95 (Fas) in sun‐exposed human skin and cutaneous carcinomas. Cancer. 2002;94(3):814-9.
Petit‐frère C, Clingen PH, Grewe M, Krutmann J, Roza L, Arlett CF, et al. Induction of Interleukin‐6 Production by Ultraviolet Radiation in Normal Human Epidermal Keratinocytes and in a Human Keratinocyte Cell Line is Mediated by DNA Damage. Journal of investigative dermatology. 1998;111(3).
Sharquie KE, Noaimi AA, Al‐Jobori AA. Skin tumors and skin infections in kidney transplant recipients vs. patients with pemphigus vulgaris. International Journal of Dermatology. 2014;53(3):288-93.
Sharquie K, Noaimi A, Bandar A, Mohsin S. Vitiligo: Skin Malignancies and Tumor Suppressive Marker P53. Pigmentary Disorders. 2014;1(1).
Sharquie KE, Noaimi AA, Burhan ZT. The frequency of skin tumors and infections in patients with autoimmune diseases. Journal of Cosmetics, Dermatological Sciences and Applications. 2016;6(4):140-7.
Sharquie KE, Al-Jaralla FA, Abulhail MA. Frequency of skin infections and tumors among patients with psoriasis. Our Dermatol Online. 2022;13:126-31.
Chockalingam R, Downing C, Tyring SK. Cutaneous squamous cell carcinomas in organ transplant recipients. Journal of clinical medicine. 2015;4(6):1229-39.
Elder DE. Lever's Histopathology of the Skin: Lippincott Williams & Wilkins; 2014.
Bakhtiari S, Mortazavi H, Mehdipour M, Jafarian N, Ranjbari N, Rahmani S. Frequency of head and neck squamous cell carcinomas and related variables in Southern Iran (Ahvaz City): 10-year retrospective study. Asian Pacific Journal of Cancer Prevention: APJCP. 2017;18(2):375.
Abdulai AE, Nuamah IK. Squamous Cell Carcinoma of the Oral cavity and Oropharynx in Ghanaians:-A study of Histopathological Charts over 20 years. World Journal of Surgical Medical and Radiation Oncology. 2013;2(7).
Sadri D, Khodayari A, Gharvan S. Prevalence of oral squamous cell carcinoma in a group of young and old Iranian patients. Journal of Dentistry. 2011;12(2):120-6.
Weinstein IB, Joe AK. Mechanisms of disease: oncogene addiction—a rationale for molecular targeting in cancer therapy. Nature clinical practice Oncology. 2006;3(8):448-57.
Seebode C, Lehmann J, Emmert S. Photocarcinogenesis and skin cancer prevention strategies. Anticancer research. 2016;36(3):1371-8.
Battie C, Verschoore M. Cutaneous solar ultraviolet exposure and clinical aspects of photodamage. Indian Journal of Dermatology, Venereology and Leprology. 2012;78:9.
Huang XX, Bernerd F, Halliday GM. Ultraviolet A within sunlight induces mutations in the epidermal basal layer of engineered human skin. The American journal of pathology. 2009;174(4):1534-43.
Wollina U, Krönert C, Schönlebe J, Vojvodic A, Lotti T. Giant squamous cell carcinoma on chronic lichen planus on the ankle-a case report and short literature review. Open Access Macedonian Journal of Medical Sciences. 2019;7(18):3061.
Laniosz V, Torgerson RR, Ramos‐Rodriguez AJ, Ma JE, Mara KC, Weaver AL, et al. Incidence of squamous cell carcinoma in oral lichen planus: a 25‐year population‐based study. International journal of dermatology. 2019;58(3):296-301.
Bombeccari GP, Guzzi G, Tettamanti M, Giannì AB, Baj A, Pallotti F, et al. Oral lichen planus and malignant transformation: a longitudinal cohort study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2011;112(3):328-34.
Phillips TJ, Salman SM, Bhawan J, Rogers GS. Burn scar carcinoma: Diagnosis and management. Dermatologic surgery. 1998;24(5):561-5.
Iannacone MR, Wang W, Stockwell HG, O’Rourke K, Giuliano AR, Sondak VK, et al. Patterns and timing of sunlight exposure and risk of basal cell and squamous cell carcinomas of the skin–a case–control study. BMC cancer. 2012;12:1-11.
