The impact of COVID-19 infection on botulinum toxin hypersensitivity: Case report and literature review
Keywords:
COVID-19, Botulinum toxin hypersensitivity, Periorbital swelling, Face wrinklesAbstract
COVID-19 infection showed specific and nonspecific triggering of the immune system with different skin manifestations. Botulinum neurotoxin type A is the most commonly used injectable drug in a cosmetic procedure, and there are few reports regarding the interaction with COVID-19. Herein, an adult woman underwent a local cosmetic botulinum neurotoxin type A injection and unfortunately, at the same time, she was diagnosed with COVID-19 infection. After 4 hours following injection, the patient developed local pain and pruritus with periorbital swelling and red plaques involving the medial canthus and lower eyelids, with erythema that spread to both cheeks. Previously, she had a history of uncomplicated twice cosmetic botulinum neurotoxin type A procedures for face wrinkles. An outpouring of several cases of hyper-reactivity to cosmetic botulinum neurotoxin type A might happened during COVID-19 pandemic. During cosmetic procedures, dermatologists and plastic surgeons should be aware of the possibility of life-threatening anaphylaxis that might happen during COVID-19 infection or its vaccination.References
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