Allogeneic mesenchymal stem cells therapy for burn wound rat model: A systematic review and meta-analysis
Keywords:
allogeneic, mesenchymal, stem cells, burn, ratAbstract
Background: Burn wounds are a burdensome problem affecting many people and cause high morbidity and mortality. Therefore, a more effective burn wound treatment is urgently needed. Objective: To evaluate the allogeneic mesenchymal stem cells’ efficacy in treating burn wounds in rats. Method: English articles were collected from the following databases: ProQuest, PubMed, EBSCOhost, SAGE, JSTOR, GARUDA, and Open Gray (January 1st, 2011, to March 29th, 2020). The inclusion criteria are original articles, rat burns experimental models, stem cells therapy using MSCs for experimental groups, non-functional solution, excipient or no treatment for control group, and healing rate of the burn wounds as the main outcome. Results and discussion: We found 9 articles in English. Hot plates or radiation were used to create burn model in 170 rats. The burn wounds degree ranged from partial (n = 2) to full-thickness (n = 4). Around 0.1–3.2 million stem cells were administered through various routes. The wound re-epithelialization rate was analyzed statistically and is shown more significant in the treatment group. Conclusion: Allogeneic MSCs may have benefits for treating burn wounds, although more experiments are still needed. RCTs are recommended to evaluate the efficacy and adverse effects of the MSCs treatment. Keywords: allogeneic; mesenchymal; stem cells; burn; ratReferences
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