Comparison of 5% potassium hydroxide with 10% potassium hydroxide solution in treatment of molluscum contagiosum: A comparative study
Keywords:
Molluscum contagiosum, potassium hydroxide, efficacy, safetyAbstract
Objective To compare the results of 5% KOH versus 10% KOH in treatment of molluscum contagiosum (MC). Methods 40 children having MC were divided into 2 groups. 5% KOH solution or 10% KOH solution was applied by the patient or a parent on lesions once daily for two weeks or till the appearance of inflammatory signs. Patients were followed up 2, 4, 8 and 12 weeks for efficacy and side effect. Efficacy was categorized as complete remission (³ 90% clearance of lesions), partial remission (60-90% clearance of lesions) and insignificant improvement (<60% clearance of lesions). Results By the end of study 16 patients in group A (5% KOH) and 17 patients in group B (10% KOH) were evaluable. Partial remission was seen in 4 (25%) in group A while in group B, 7 (41.2%) patients showed complete remission and 10 (58.8%) partial remission. 100% patients in group B showed local side effect in group A and 52.3% developed local side effect in group B. The side effects were mild and did not require discontinuation of treatment. Conclusion 10% KOH solution is more effective treatment option for molluscum contagiosum than 5% KOH solution.References
Chen X, Anstey AV, Bugert JJ. Molluscum contagiosum virus infection. Lancet Infect Dis. 2013;13:877-88.
Potassium hydroxide. Available from: http://en.wikipedia.org/wiki/Potassium_hydroxide. Accessed on July 14, 2014.
Muzaffar F. 10% Potassium hydroxide solution vs. cryotherapy in the treatment of molluscum contagiosum: A case-control study. J Pak Assoc Dermatol. 2011;21:185-9.
Romiti R, Ribeiro AP, Grinblat GM et al. Treatment of molluscum contagiosum with potassium hydroxide: A clinical approach in 35 children. Pediatr Dermatol. 1999; 16:228-31.
Short KA, Fuller C, Higgins EM. Double-blind, randomized placebo-controlled trial of the use of topical 10% potassium hydroxide solution in the treatment of molluscum contagiosum. Pediatr Dermatol. 2006;23:279-81.
Can B, Topaloglu F, Kavala M et al. Treatment of pediatric molluscum contagiosum with 10% potassium hydroxide solution. J Dermatolog Treat. 2014;25:246-8.
Handjani F, Behazin E, Sadati MS et al. Comparison of 10% potassium hydroxide solution versus cryotherapy in the treatment of molluscum contagiosum: an open randomized clinical trial. J Dermatolog Treat. 2014;25:249-50.
Metkar A, Pande S, Khopkar U. An open, nonrandomized, comparative study of imiquimod 5% cream versus 10% potassium hydroxide solution in the treatment of molluscum contagiosum. Indian J Dermatol Venereol Leprol. 2008;74:614-8.
Seo SH, Chin HW, Jeong DW, Sung HW. An open, randomized, comparative clinical and histological study of imiquimod 5% cream versus 10% potassium hydroxide solution in the treatment of molluscum contagiosum. Ann Dermatol. 2010;22:156-62.
Köse O, Özmen I, Arca E. An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children. J Dermatolog Treat. 2013;24:300-4.
Romiti R, Ribeiro AP, Romiti N. Evaluation of the effectiveness of 5% potassium hydroxide for the treatment of molluscum contagiosum. Pediatr Dermatol. 2000;17:495.
Rajouria EA, Amatya A, Karn D. Comparative study of 5% potassium hydroxide solution versus 0.05% tretinoin cream for molluscum contagiosum in children. Kathmandu Univ Med J. 2011;9:291-4.
Uçmak D, Akkurt MZ, Kacar SD et al. Comparative study of 5% and 2.5% potassium hydroxide solution for molluscum contagiosum in children. Cutan Ocul Toxicol. 2014;33:54-9.
Brady G, Bowie AG. Innate immune activation of NFκB and its antagonism by poxviruses. Cytokine Growth Factor Rev. 2014;25:611-20.
