Frequency of dyslipidemia in patients with psoriasis
DOI:
https://doi.org/10.66344/jpad.24.4.2014.218Keywords:
Psoriasis, dyslipidemiaAbstract
Objective To determine the frequency of dyslipidaemia in psoriatic patients. Methods A cross-sectional study was carried out in the Department of Dermatology, Jinnah hospital, Lahore for the duration of six months. A total of 120 patients suffering from psoriasis, of any severity, belonging to either sex and with age between 15-70 years were included in the study. All patients in the study were investigated for total cholesterol, triglycerides, low-density lipoproteins and high-density lipoproteins after 12-14 hours of overnight fasting. Results The mean age of the patients was 38.59 ± 13.86 years. There were 78 (65%) male and 42 (35%) female patients. The mean duration of psoriasis was 5.46 ± 4.49 years. The mean PASI score was 14.98 ± 8.95. There were 67 (55.8%) patients having dyslipidaemia and 53 (44.2%) patients had normal lipid levels. 34 (28.3%) patients had raised total cholesterol (>200mg/dl), 32 (26.7%) raised low-density lipoprotein-cholesterol (>130 mg/dl), 44 (36.7%) hypertriglyceridemia (>150mg/dl) and 35 (29.2%) patients had reduced high-density lipoprotein-cholesterol levels (<40mg/dl). Conclusion It is concluded from this study that patients of psoriasis have a high incidence of dyslipidaemia, as it was found in 55.8% of psoriatic patients.  ÂReferences
Myers WA, Gottlieb AB, Mease P. Psoriasis and psoriatic arthritis: clinical features and disease mechanisms. Clin Dermatol. 2006;24:438-47.
Gelfand JM, Stern RS, Nijsten T et al. The prevalence of psoriasis in African Americans: results from a population- based study. J Am Acad Dermatol. 2005;52:23-6.
Gudjonsson JE, Elder JT. Psoriasis. Fitzpatrick’s Dermatology In General Medicine, 7th ed. New York: McGraw-Hill; 2008. P. 169-93.
Bajaj DR, Mahesar SM, Devrajani BR, Iqbal MP. Lipid profile in patients with psoriasis presenting at Liaquat University Hospital Hyderabad. J Pak Assoc Dermatol. 2009;59:512-5.
Akhyani M, Ehsani AH, Robati RM, Robati AM. The lipid profile in psoriasis: a controlled study. J Eur Acad Dermatol Venereol. 2007;21:1330-2.
Dreiher J, Weitzman D, Davidovici B et al. Psoriasis and dyslipidaemia: A population-based study. Acta Derm Venereol. 2008;88:561-5.
Cohen AD, Gilutz H, Henkin Y et al. Psoriasis and the metabolic syndrome. Acta Derm Venereol. 2007;87:506-9.
Cohen AD, Sherf M, Vidavsky L et al. Association between psoriasis and the metabolic syndrome. A cross-sectional study. Dermatology. 2008;216:152-5.
Brauchli YB, Jick SS, Meier CR. Psoriasis and the risk of incident diabetes mellitus: a population-based study. Br J Dermatol. 2008;159:1331-7.
Späh F. Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. Br J Dermatol. 2008;159 (suppl 2):10-7.
Brauchli YB, Jick SS, Miret M, Meier CR. Psoriasis and the risk of incident myocardial infarction, stroke or transient ischaemic attack: an inception cohort study with a nested case-control analysis. Br J Dermatol. 2009;160:1048-56.
Prodanovich S, Kirsner RS, Kravetz JD et al. Association of psoriasis with coronary artery, cerebrovascular and peripheral vascular diseases and mortality. Arch Dermatol. 2009;145:700-3.
Escarcega RO, Garcia-Carrasco M, Fuentes-Alexandro S et al. Insulin resistance, chronic inflammatory state and the link with systemic lupus erythematosus-related coronary disease. Autoimmun Rev. 2006;6:48-53.
Aprahamian T, Rifkin I, Bonegio R et al. Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med. 2004;199:1121-31.
Neimann AL, Shin DB, Wang X et al. Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol. 2006;55:829-35.
Farshchian M, Zamanian A, Farshchian M et al. Serum lipid level in Iranian patients with psoriasis. J Eur Acad Dermatol Venereol. 2007;21:802-5.
Javidi Z, Meibodi NT, Nahidi Y. Serum lipids abnormalities and psoriasis. Indian J Dermatol. 2007;52:89-92.
Piskin S, Gurkok F, Ekuklu G, Senol M. Serum lipid levels in psoriasis. Yonsei Med J. 2003;44:24-6.
Mallbris L, Granath F, Hamsten A, Stahl M. Psoriasis is associated with lipid abnormalities at the onset of skin disease. J Am Acad Dermatol. 2006;54:614-21.
Tekin NS, Tekin IO, Barut F, Sipahi EY. Accumulation of oxidized low-density lipoprotein in psoriatic skin and changes of plasma lipid levels in psoriatic patients. Mediators Inflamm. 2007;2007:78454
Iqbal SP, Dodani S, Qureshi R. Risk factors and behaviors for coronary artery disease (CAD) among ambulatory Pakistanis. J Pak Med Assoc. 2004;54:261-6.
Downloads
Published
How to Cite
Issue
Section
License
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.
