Clinico-sociodemographic Profile of Leprosy Neuropathy in Medan, Indonesia
DOI:
https://doi.org/10.66344/jpad.33.1.2023.2059Keywords:
Disability, leprosy, neuropathy, Semmes-Weinstein monofilamentsAbstract
Background: Leprosy neuropathy is still a serious health issue in emerging and underdeveloped nations. Nerve damage caused by leprosy that is not handled properly and quickly will cause disability. Therefore, information about characteristic of leprosy patients with neuropathy is very necessary. The purpose of this study is to identify the clinico-sociodemographic characteristics of leprosy patients who have neuropathy. Methods: This is a cross-sectional descriptive study that uses the consecutive sampling strategy on 21 leprosy patients who have neuropathy. Leprosy neuropathy was examined using Semmes-Weinstein monofilaments. Results: Sociodemographic characteristics were mostly in the age group 18-35 years (57.1%), male (85.7%), secondary education level (57.1%), and work as employee (33.3%). The majority of the research subjects were multibacillary (MB) type leprosy (100%), experiencing leprosy reactions (42.9%), release from treatment (RFT) (47.6%), leprosy duration >12 months (57.1%), experienced symptoms of neuropathy (95.2 %), duration of neuropathy symptoms ≤ 1 year (52.4%), neuropathy location in the lower bilateral extremities (52.4%), and did not have a grade 2 leprosy disability according to WHO (90.5%). Conclusions: The majority of leprosy neuropathy patients were in the age group of 18-35 years, male, secondary education level, employee, MB type leprosy, experiencing leprosy reactions, RFT, duration of leprosy >12 months, experienced symptoms of neuropathy, duration of neuropathy symptoms ≤1 year, neuropathy location in the lower bilateral extremities, and did not have a grade 2 leprosy disability according to WHO.References
Rao PN, Suneetha SK, Ebenezer GJ. Neuritis: Definition, Clinicopathological Manifestations and Proforma to Record Nerve Impairment in Leprosy. In:Kar KH, Kumar B, editor. IAL Textbook of Leprosy. 2nd ed. London: Churchil Livingstone; 2017:397-413.
Putri NU, Widasmara D. Neuropati kusta. Media Dermato-Venereologica Indosiana 2020;47(1):106-10.
Kementerian Kesehatan Republik Indonesia. Temukan kusta sejak dini:tidak ada kecacatan, tidak ada stigma. Jakarta: Kementerian Kesehatan Republik Indonesia; 2017. [ cited 2021 February 22]. Available from:
https://www.kemkes.go.id/article/print/17013000001/temukan-kusta-sejak-dini-tidak-ada-kecacatan-tidak-ada-stigma-.html.
Dinas Kesehatan Kota Medan. Profil kesehatan kota Medan tahun 2016. Medan: Dinas Kesehatan Kota Medan; 2016.
Widasmara D, Panjarwanto DA, Sananta P. The correlation of semmes-weinstein monofilament test with the level of p-75 neurotrophin as marker of nerve damage in leprosy. Clin Cosmet Investig Dermatol. 2020;13:399-404.
Nascimento OJM. Leprosy neuropathy: Clinical presentations. Arq Neuropsiquiatr. 2013;71(9 B):661-6.
Rusyati LMM, Sasmita PA, Adiguna MS. Diagnostic test using monofilament compared to electroneuromyography (ENMG) for detection of peripheral neuropathy in leprosy at Sanglah General Hospital, Bali-Indonesia. Bali Med J. 2019;8(3):722-7.
Sermrittirong S, Van Brakel W H. Stigma in leprosy: concepts, causes and determinants. In: Sermrittirong S. Stigma and stigma interventions related to leprosy and tuberculosis in Thailand. Ridderprint, Ridderkerk, The Netherlands. 2014:39-51.
Kar S, Krishnan A, Singh N, et al. Nerve damage in leprosy: An electrophysiological evaluation of ulnar and median nerves in patients with clinical neural deficits: A pilot study. Indian Dermatol Online J. 2013;4(2):97-101.
Sari D, Widasmara D, Kurniawan S. Case Report Interpretation of Nerve Conduction Study in Polyneuropathy With Multibacillary Leprosy Type 2 Reaction. Malang Neu J. 2018;4(2):86-95.
De Freitas MRG, Nascimento OJM, Quaglino EAM, et al. Small-fiber polyneuropathy in leprosy without skin changes: Study of 17 cases. Arq Neuropsiquiatr. 2003;61(3A):542-6.
Garbino JA, Naafs B, Salgado MH, et al. Association between neuropathic pain and a-waves in leprosy patients with type 1 and 2 reactions. J Clin Neurophysiol. 2011;28(3):329-32.
Faridi M, Widyadharma P, Susilawathi N. Factors that are correlated with the incidence of peripheral neuropathy in patients with Morbus Hansen at Sanglah Hospital Denpasar in 2018. Int J Med Rev Case Rep. 2020;4(4):1-5.
Ridley DS, Ridley MJ. Classification of nerves is modified by the delayed recognition of Mycobacterium leprae. Int J Lepr. 1986;54(4):596-606.
Shetty VP. Chapter 11: Pathomechanisms of Nerve Damage. In: Kar H.K., Kumar B. (Eds.); Indian Association of Leprologists Textbook of Leprosy. 2nd edition. New Delhi; Jaypee Brothers Medical Publisher (P) Ltd; 2017, p.170-81
Van Brakel WH, Nicholls PG, Das L, et al. Erratum: The INFIR cohort study: Investigating prediction, detection and pathogenesis of neuropathy and reactions in leprosy. Methods and baseline results of a cohort of multibacillary leprosy patients in North India. Lepr Rev. 2005;76(3):14-34.
Rathod SP, Jagati A, Chowdhary P. Disabilities in leprosy: An open, retrospective analyses of institutional records. An Bras Dermatol. 2020;95(1):52-6.
Khadilkar SV, Patil SB, Shetty VP. Neuropathies of leprosy. J Neurol Sci. 2021;420:117288.
Novita H, Kurniani N, Birawa ABP. Uji sensitivitas tes monofilamen untuk deteksi dini neuropati kusta subklinis pada kontak erat pasien kusta tipe multibasilar. Neurona. 2016;33(4):273-8.
Soomro FR, Pathan GM, Abbasi P, et al. Deformity and disability index in patients of leprosy in Larkana region. J Pakistan Assoc Dermatol. 2008;18(1):29-32.
Richardus JH, Nicholls PG, Croft RP, et al. Incidence of acute nerve function impairment and reactions in leprosy: A prospective cohort analysis after 5 years of follow-up. Int J Epidemiol. 2004;33(2):337-43.
Downloads
Published
How to Cite
Issue
Section
License
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.