Evaluation of quality of life in patients with Mycosis fungoides in Isfahan in 2017-2019
Keywords:
Mycosis fungoides, quality of life, skin lesions, SF-36Abstract
Objective Mycosis fungoides (MF) is a condition of the lymphatic tissues that mostly affects the skin (primary cutaneous T cell lymphoma), the most prevalent form of T-cell skin lymphoma. Central lymph node and other organs involvement are very poor prognostic factors that can gradually affect the quality of life of these patients. Therefore, in this study, we aimed to examine the quality of life in patients with MF.  Methods In this descriptive study, a demographic questionnaire including age, gender, duration of MF, stage of the disease, and location of the lesion was completed. All participants were tested for quality of life using the SF36 questionnaire.  Results  There was a significant difference between different stages of the disease as well as the duration of the disease with respect to the overall quality of life score and its subscales, so that with increasing stage and duration of the disease, the quality of life decreased (P <0.05). The quality of life was lower in patients with sun-exposed areas than in those with other affected areas (P <0.05).  Conclusion MF disease is correlated with reduced quality of life and the extent of which is inversely related to the duration of the disease as well as the stage of the disease. Additionally, patients with affected areas that are exposed to sunlight have a lower quality of life than those with other affected areas.References
Whittaker S, Hoppe R, Prince HM. How I treat mycosis fungoides and Sezary syndrome. Blood, J Am Soc Hematol. 2016;127(25):3142-53.
Hristov AC, Tejasvi T, Wilcox RA. Mycosis fungoides and Sézary syndrome: 2019 update on diagnosis, riskâ€stratification, and management. Am J Hematol. 2019;94(9):1027-41.
Kamijo H, Sugaya M. Two distinct variants of mycosis fungoides (MF): Folliculotropic MF and erythrodermic MF. J Dermatol. 2019;46(12):1136-40.
Lim H, Tan E, Tee S, Ho Z, Boey J, Tan W, et al. Epidemiology and prognostic factors for mycosis fungoides and Sézary syndrome in a multiâ€ethnic Asian cohort: a 12â€year review. J Eur Acad Dermatol Venereol. 2019;33(8):1513-21.
Board PATE. Mycosis Fungoides (Including Sézary Syndrome) Treatment (PDQ®). PDQ Cancer Information Summaries [Internet]: National Cancer Institute (US); 2019.
Martinez XU, Di Raimondo C, Abdulla FR, Zain J, Rosen ST, Querfeld C. Leukaemic variants of cutaneous T-cell lymphoma: Erythrodermic mycosis fungoides and Sézary syndrome. Best Practice & Research Clinical Haematology. 2019.
Wu JH, Cohen BA, Sweren RJ. Mycosis fungoides in pediatric patients: Clinical features, diagnostic challenges, and advances in therapeutic management. Pediatr Dermatol. 2020;37(1):18-28.
McCaffrey S, Black RA, Nagao M, Sepassi M, Sharma G, Thornton S, et al. Measurement of Quality of Life in Patients with Mycosis Fungoides/Sézary Syndrome Cutaneous T-Cell Lymphoma: Development of an Electronic Instrument. J Med Int Res. 2019;21(1):e11302.
Molloy K, Evison F, Peng C, Guenova E, Cowan R, Busschots A, et al. Quality of life in patients with mycosis fungoides and Sezary syndrome is significantly worse in female patients, Sezary syndrome and those with more extensive skin involvement. Eur J Cancer. 2018;101:S39.
Wright A, Wijeratne A, Hung T, Gao W, Whittaker S, Morris S, et al. Prevalence and severity of pruritus and quality of life in patients with cutaneous T-cell lymphoma. J Pain Symp Manag. 2013;45(1):114-9.
Sampogna F, Frontani M, Baliva G, Lombardo G, Alvetreti G, Di Pietro C, et al. Quality of life and psychological distress in patients with cutaneous lymphoma. Br J Dermatol. 2009;160(4):815-22.
Sanclemente G, Burgos C, Nova J, Hernández F, González C, Reyes M, et al. The impact of skin diseases on quality of life: A multicenter study. Actas Dermo-Sifiliográficas (English Edition). 2017;108(3):244-52.
Mols F, Aaronson NK, Vingerhoets AJ, Coebergh JWW, Vreugdenhil G, Lybeert ML, et al. Quality of life among longâ€term nonâ€Hodgkin lymphoma survivors: a populationâ€based study. Cancer: Interdisciplinary International Journal of the American Cancer Society. 2007;109(8):1659-67.
Smith SK, Zimmerman S, Williams CS, Zebrack BJ. Health status and quality of life among nonâ€Hodgkin lymphoma survivors. Cancer: Interdisciplinary International Journal of the American Cancer Society. 2009;115(14):3312-23.
Smith SK, Crespi CM, Petersen L, Zimmerman S, Ganz PA. The impact of cancer and quality of life for postâ€treatment nonâ€Hodgkin lymphoma survivors. Psychooncology. 2010;19(12):1259-67.
Soares A, Biasoli I, Scheliga A, Baptista R, Brabo E, Morais J, et al. Association of social network and social support with health-related quality of life and fatigue in long-term survivors of Hodgkin lymphoma. Supportive Care in Cancer. 2013; 21(8):2153-9.
Arden-Close E, Pacey A, Eiser C. Health-related quality of life in survivors of lymphoma: a systematic review and methodological critique. Leukemia & lymphoma. 2010;51(4):628-40.
Nazik H, Nazik S, Gul FC. Body image, self-esteem, and quality of life in patients with psoriasis. Indian D Online J. 2017;8(5):343.
Blome C, Radtke MA, Eissing L, Augustin M. Quality of life in patients with atopic dermatitis: disease burden, measurement, and treatment benefit. American J Clin Dermatol. 2016;17(2):163-9.
Cazzaniga S, Ballmerâ€Weber BK, Gräni N, Spring P, Bircher A, Anliker M, et al. Chronic hand eczema: a prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement. Contact Dermatitis. 2018;79(3):136-48.
