Actinic granuloma over photo exposed and covered parts
Keywords:
Photoexposed, annular, granulomaAbstract
Actinic granuloma, also known as an annular elastolytic giant cell granuloma variant, is a chronic granulomatous condition. It is relatively a rare condition triggered by various factors like prolonged exposure to the sun, which initiate an immune response leading to changes in elastic tissue. We report a 69-year-old man who presented with a complaint of a reddish ring-like rash over both thighs, inner aspect of right elbow, back of the neck for two months. He was treated with topical tacrolimus for two months and responded well. The clinical picture of actinic granuloma is similar to that of granuloma annulare; hence they should be differentiated from each other based on histopathology. The histopathological picture of actinic granuloma mainly shows elastolysis, elastophagocytosis, and multinucleate giant cellsReferences
Coutinho, Inês D et al. O'Brien Actinic Granuloma: A Case Report and Brief Review of Literature. Indian J Dermatol. 2015;60(4):391-3.
Christopher R. Lovell. Acquired disorders of dermal connective tissue. Rook's Text Book of Dermatology, 9th ed. West Sussex: John Wiley & Sons;2016. p.96.25-26.
O’Brien JP. Actinic granuloma. An annular connective tissue disorder affecting sun and heat damaged (elastotic) skin. Arch Dermatol. 1975;111:460-6.
Wang C-Y, Pujol RM, Lee W-H, Su W-P. Annular elastolytic granuloma: a clinicopathologic study of 15 cases and a literature review. Dermatol-Sinica. 1996; 14:51-64.
Weedon D. Elastolytic granulomas. In: Weedon D. Weedon’s Skin Pathology, 3rd ed. London: Churchill-Livingstone, 2010:188-9.
Al-Hoqail IA, Al-Ghamdi AM, Martinka M, Crawford RI. Actinic granuloma is a unique and distinct entity. Am J Dermatopathol. 2002;24:209-12.
The granulomatous reaction pattern. In: David Weedon. Skin Pathology. 2nd Edition (Elsevier). New York: Churchill Livingstone; 2002. p. 193-220.