An Unusual concurrence of pyoderma gangrenosum and HCV infection: A case report
DOI:
https://doi.org/10.66344/jpad.v32i3.1977Abstract
Pyoderma gangrenosum, an inflammatory dermatosis, having a rare occurrence of 3-5 per million population has known to be associated with some of the underlying systemic diseases in about one-half of the cases. Its association with HCV, although contemplated, has rarely been reported in literature. Hepatitis C viral infection can present with varied extrahepatic manifestations. Case reports and studies, although few, associates pyoderma gangrenosum as one of its extrahepatic-manifestation. We present one such case of pyoderma gangrenosum where HCV infection is suspected to be the underlying cause. This case report is expected to help amplify such evidences.
References
1. Chariatte N, Lysitsa S, Lombardi T, Samson J. Pyoderma gangrenosum. Part I: literature review. J Oral Med Oral Surg. 2011;17(2):121-31.
2. Wollina U. Pyoderma gangrenosum– A review. Orphanet J Rare Dis. 2007;W:1-8.
3. Pourmorteza M, Tawadros F, Bader G, Al-Tarawneh M, Cook E, Shams W, Young M. Successful treatment of pyoderma gangrenosum with cryoglobulinemia and hepatitis C. Am J Med Case Rep. 2016;17:434.
4. Binus AM, Qureshi AA, Li VW, Winterfield LS. Pyoderma gangrenosum: a retrospective review of patient characteristics, comorbidities and therapy in 103 patients. Br J Dermatol. 2011;165(6):1244-50.
5. Keane FM, MacFarlane CS, Munn SE, Higgins EM. Pyoderma gangrenosum and hepatitis C virus infection. Br J Dermatol. 1998;139(5):924-5.
6. Yurci A, Guven K, Torun E, Gursoy S, Baskol M, Akgun H, Ozbakir O, Yucesoy M. Pyoderma gangrenosum and exacerbation of psoriasis resulting from pegylated interferon alpha and ribavirin treatment of chronic hepatitis C. Eur J Gastroenterol Hepatol. 2007;19(9):811-5.
7. Smith JB, Shenefelt PD, Soto O, Valeriano J. Pyoderma gangrenosum in a patient with cryoglobulinemia and hepatitis C successfully treated with interferon alfa. J Am Acad Dermatol. 1996;34(5):901-3.
8. Kondo Y, Iwata T, Haga T, Kimura O, Ninomiya M, Kakazu E, Kogure T, Morosawa T, Aiba S, Shimosegawa T. Eradication of hepatitis C virus could improve immunological status and pyoderma gangrenosum‐like lesions. Hepatol Res. 2014;44(2):238-45.
9. Mando R, Balagoni H, Locke A, Swenson J, Young M. Untreated Hepatitis C Presenting with Pyoderma Gangrenosum: 2693. Am J Gastroenterol ACG. 2016;111:S1354.
10. Kimura K. Should we try antiviral therapy for hepatitis C virus infection with pyoderma gangrenosum‐like lesions? Hepatol Res. 2014;44(2):173-5.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Sahibpreet Kaur Sahibpreet Kaur, Dr Tejinder Kaur Tejinder Kaur

This work is licensed under a Creative Commons Attribution 4.0 International License.
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.






