An Unusual concurrence of pyoderma gangrenosum and HCV infection: A case report

Authors

  • Sahibpreet Kaur Department of Dermatology, Government Medical College Amritsar, India
  • Tejinder Kaur Department of Dermatology, Government Medical College Amritsar, India

DOI:

https://doi.org/10.66344/jpad.v32i3.1977

Abstract

Pyoderma gangrenosum, an inflammatory dermatosis, having a rare occurrence of 3-5 per million population has known to be associated with some of the underlying systemic diseases in about one-half of the cases. Its association with HCV, although contemplated, has rarely been reported in literature. Hepatitis C viral infection can present with varied extrahepatic manifestations. Case reports and studies, although few, associates pyoderma gangrenosum as one of its extrahepatic-manifestation. We present one such case of pyoderma gangrenosum where HCV infection is suspected to be the underlying cause. This case report is expected to help amplify such evidences.

Author Biography

  • Tejinder Kaur, Department of Dermatology, Government Medical College Amritsar, India

    Professor and head, department of dermatology, Government Medical College Amritsar

References

1. Chariatte N, Lysitsa S, Lombardi T, Samson J. Pyoderma gangrenosum. Part I: literature review. J Oral Med Oral Surg. 2011;17(2):121-31.

2. Wollina U. Pyoderma gangrenosum– A review. Orphanet J Rare Dis. 2007;W:1-8.

3. Pourmorteza M, Tawadros F, Bader G, Al-Tarawneh M, Cook E, Shams W, Young M. Successful treatment of pyoderma gangrenosum with cryoglobulinemia and hepatitis C. Am J Med Case Rep. 2016;17:434.

4. Binus AM, Qureshi AA, Li VW, Winterfield LS. Pyoderma gangrenosum: a retrospective review of patient characteristics, comorbidities and therapy in 103 patients. Br J Dermatol. 2011;165(6):1244-50.

5. Keane FM, MacFarlane CS, Munn SE, Higgins EM. Pyoderma gangrenosum and hepatitis C virus infection. Br J Dermatol. 1998;139(5):924-5.

6. Yurci A, Guven K, Torun E, Gursoy S, Baskol M, Akgun H, Ozbakir O, Yucesoy M. Pyoderma gangrenosum and exacerbation of psoriasis resulting from pegylated interferon alpha and ribavirin treatment of chronic hepatitis C. Eur J Gastroenterol Hepatol. 2007;19(9):811-5.

7. Smith JB, Shenefelt PD, Soto O, Valeriano J. Pyoderma gangrenosum in a patient with cryoglobulinemia and hepatitis C successfully treated with interferon alfa. J Am Acad Dermatol. 1996;34(5):901-3.

8. Kondo Y, Iwata T, Haga T, Kimura O, Ninomiya M, Kakazu E, Kogure T, Morosawa T, Aiba S, Shimosegawa T. Eradication of hepatitis C virus could improve immunological status and pyoderma gangrenosum‐like lesions. Hepatol Res. 2014;44(2):238-45.

9. Mando R, Balagoni H, Locke A, Swenson J, Young M. Untreated Hepatitis C Presenting with Pyoderma Gangrenosum: 2693. Am J Gastroenterol ACG. 2016;111:S1354.

10. Kimura K. Should we try antiviral therapy for hepatitis C virus infection with pyoderma gangrenosum‐like lesions? Hepatol Res. 2014;44(2):173-5.

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Published

27.08.2022

Issue

Section

Case Reports

How to Cite

1.
An Unusual concurrence of pyoderma gangrenosum and HCV infection: A case report. J Pak Assoc Dermatol [Internet]. 2022 Aug. 27 [cited 2026 Sep. 14];32(3):638-41. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/1977