Chronic erythema nodosum as a sign of tuberculosis infection
DOI:
https://doi.org/10.66344/jpad.v32i3.1965Abstract
Introduction Erythema nodosum (EN) is a subcutaneous fat tissue inflammation (pannicullitis) characterized by diffuse erythematous nodules symmetrically distributed in the anterior part of the lower extremities. EN is considered a reactive process that can be triggered by a wide variety of factors including mycobacterium (M.) tuberculosis infection.
Case A 21-year-old woman, presented in our department with a 9-month-history of painful erythematous nodules on both legs accompanied by ankle swelling and joint pain. Previous treatments with amoxicillin-clavulanic acid, steroid, and nonsteroidal anti-inflammatory drugs (NSAIDs) did not yield satisfactory results. On examination, we found multiple tender erythematous nodules symmetrically distributed on both legs. On laboratory examination, C-reactive protein and erythrocyte sedimentation rate were increased, interferon-gamma release assay (IGRA) test was found positive for M. tuberculosis infection. The patient was treated with a standard anti-tuberculosis regimen. At 3-month follow-up, all the skin lesions had disappeared. The patient did not report any recurrence after 1 year of follow-up.
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Copyright (c) 2022 dr. Tara Sefanya Kairupan, M.Kes, Ph.D, dr. Aryani Adji, Sp.KK(K), FINSDV, FAADV, dr. Marlyn Grace Kapantow, Sp.KK(K), FINSDV, FAADV
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