Correlation Between Bacterial Index and Grade of Disability Amongst Leprosy Patients : A Single Center Retrospetive Study

Authors

  • Felix Hartanto Dr. Soetomo General Hospital
  • Tessa Thendria Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
  • Regitta Indira Agusni Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
  • Bagus Haryo Kusumaputra Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
  • Medhi Denisa Alinda Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
  • Muhammad Yulianto Listiawan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
  • Evy Ervianti Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
  • Cita Rosita Sigit Prakoeswa Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

DOI:

https://doi.org/10.66344/jpad.v32i3.1944

Abstract

Background  Leprosy occurs due to primary M. leprae infection that attacks the peripheral nerves. Limited resources directly links the bacterial index (BI) with the grade of disability in leprosy patients in Indonesia, even though the problem of disability greatly affects quality of life of patients.

 

Methods A cross-sectional retrospective study approach was conducted. Total sampling technique was performed from medical records of patients with diagnosis of PB or MB leprosy, accompanied by grade 0, 1 or 2 disability. Correlation analysis test was performed to determine the correlation between BI and grade of disability in leprosy patients.

 

Results  A total of 278 patients were included in this study, divided into 13 patients (4.7%) of PB leprosy and 265 patients (95.3%) of MB leprosy. Significant results were obtained in 5 out of 9 groups: (a) hand group in PB+MB leprosy (p value: 0.047); (b) foot group in PB+MB leprosy (p value: 0.002); (c) foot group in PB leprosy (p value: 0.000); (d) hand group in MB leprosy (p value: 0.021); and (e) foot group in MB leprosy (p value: 0.006).

 

Conclusion Positive correlations between BI and grade of disability were found in 56% of the analysis groups.

 

References

1. Sari DT, Widasmara D, Kurniawan SN. Interpretation of nerve conduction study in polyneuropathy with multibacillary leprosy type 2 reaction. Malang Neurol J. 2018;4(2):86–95.

2. Das NK, De A, Naskar B, Sil A, Das S, Sarda A, et al. A quality of life study of patients with leprosy attending the dermatology OPD of a tertiary care center of Eastern India. Indian J Dermatol. 2020;65(1):42–6.

3. Hambridge T, Chandran SLN, Geluk A, Saunderson P, Richardus JH. Mycobacterium leprae transmission characteristics during the declining stages of leprosy incidence: A systematic review [Internet]. PLoS Negl Trop Dis. 2021;15(5):e0009436.

4. Gautam M, Jaiswal A. Forgetting the cardinal sign is a cardinal sin: Slit-skin smear. Indian J Paediatr Dermatol. 2019;20(4):341.

5. Shetty V. Pathomechanisms of Nerve Damage. In: IAL Textbook of Leprosy. 2017. p.170.

6. Mowla MR, Angkur DM, Hasan Z, Sultana MN, Afrin S, Akhter MS. Leprosy patients with deformities at post‐elimination stage: The Bangladesh experience. Ski Heal Dis. 2021;1(1):1–8.

7. Gunawan H, Kamilia A, Menaldi SL, Marissa M, Prakoeswa CRS, Alinda MD, et al. Characteristics of grade 2 disability in indonesian children with leprosy: A five-year multicenter retrospective study. Clin Cosmet Investig Dermatol. 2021;14:1149-53.

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Published

27.08.2022

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Original Articles

How to Cite

1.
Correlation Between Bacterial Index and Grade of Disability Amongst Leprosy Patients : A Single Center Retrospetive Study. J Pak Assoc Dermatol [Internet]. 2022 Aug. 27 [cited 2026 Sep. 14];32(3):552-6. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/1944