Mycosis Fungoides in Iraqi population; changing in frequency,demographic and clinical subtypes
DOI:
https://doi.org/10.66344/jpad.v32i3.1934Abstract
Background Mycosis fungoides (MF) is a slow-progressing primary cutaneous T-cell lymphoma. There is a paucity of literature on this condition in Iraqi population.
Objective To record and evaluate the different socio-demographic factors and clinical patterns of mycosis fungoides and their variants in Iraqi patients.
Methods The current study comprised a total of 108 participants with MF. All patients had a complete medical history and were evaluated clinically. Histopathology was performed on incisional biopsies. Only 20 patients were studied using immunohistochemistry. Laboratory tests including blood cell-count, blood levels of creatinine, urea, liver enzymes, and lactate dehydrogenase (LDH). Main outcome measures were age, gender, duration of disease, clinical subtypes, lesions distribution and staging.
Results Fifty eight (53.7%) patients had patch stage, 34 (31.5%) in the plaque stage, 8 (7.4%) in the tumor stage and 8 (7.4%) patients presented with erythroderma. In regard to clinical variants: poikiloderma was seen in 44 (40.7%) patients, lichenoid variant in 12 (11.11%) patients, hypopigmented variant in 5 (4.6%) patients, follicular MF in only one patient and granulomatous in one patient. The ordinary classical picture was observed in 45 (41.66%) patients. The most common stage at diagnosis was IA (42 patients), followed by IB (32 patients), IIA (18 patients), IIB (8 patients) and III (8 patients). Palpable lymph nodes were detected in 18 (16.66 %) patients while visceral involvement was not detected in any patient.
Conclusion Clinical pattern of MF at time of presentation has changed, mostly toward unusual variants of MF commonly poikilodermoid subtype. The rate of MF is higher in males than females.
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Copyright (c) 2022 Khalifa E. Sharquie, Fatema A. Aljaralla, Salwa F. Taha
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