Efficacy and safety of adapalene 0.1 % vs. trichloroacetic acid 30% in management of molluscum contagiosum in children: A randomised controlled trial
DOI:
https://doi.org/10.66344/jpad.v32i2.1914Abstract
Background Molluscum contagiosum is viral infection that is quite common in children. Although many treatment options are available, but these are associated with complications of pain, erythema, scarring or recurrence.
Objective Comparison of efficacy and safety of adapalene 0.1% and trichloroacetic acid 30% in management of molluscum contagiosum in children.
Methods Sample size was sixty. Participants were randomized in two groups. In group A, 30 patients were treated with TCA and in group B, 30 patients were treated with adapalene. Patients were followed for 6 weeks.
Results TCA was found safe in 21 (70%) patients vs. 29 (96.7%) in adapalene group (p<0.05). TCA was effective in 25 (83.3%) patients vs. 20 (66.7%) patients in adapalene group (p>0.05).
Conclusion It was found that TCA is more efficacious and adapalene is safer.
References
1. Criton S. Viral Infections. Chapter 14 in IADVL text book and Atlas of Dermatology, 3rd ed. Valia RG and Valia AR editors, Mumbai: Bhalani Publishing House 2008;333.
2. Sterling JC. Virus Infections. Chapter 33 in Rook’s Textbook of Dermatology. 8th ed. Burns T, Breathnach S, Cox S, Griffiths C editors, West Sussex, U.K: Blackwell Publishing Ltd., 2010;33:11.
3. Hanson D, Diven DG. Molluscum contagiosum. Dermatol Online J. 2003;9:2.
4. Gellis SE. Warts and molluscum contagiosum in children. Pediatr Ann. 1987;16:69-76.
5. Rogers M, Barneson RSC. Diseases of the skin. In: Campbell AGM, McIntosh N et al. Forfar and Arneil’s textbook of pediatrics. 5th ed. New York: Churchill Livingstone 1998;1633-1635.
6. Silverberg NB, Sidbury R, Mancini AJ. Childhood molluscum contagiosum: experience with cantharidin therapy in 300 patients. J Am Acad Dermatol. 2000;43:503-7.
7. Van der Wouden JC, van der Sande R, van Suijlekom-Smit LWA, Berger M, Butler CC, Koning S. Interventions for cutaneous molluscum contagiosum. Cochrane Database Syst Rev. 2009;4:CD004767.
8. Metkar A, Pande S, Khopkar U. An open, nonrandomized, comparative study of imiquimod 5% cream versus 10% potassium hydroxide solution in the treatment of molluscum contagiosum. Indian J Dermatol Venereol Leprol. 2008;74:614-8.
9. Macini AJ, Bodemer C. Viral infections. In: Schachner LA, Hansen RC, editors. Pediatric Dermatology. New York: Elsevier 2003;1090-2.
10. Bayerl C, Feller G, Goerdt S. Experience in treating molluscum contagiosum in children with imiquimod 5% cream. Br J Dermatol. 2003;149:25-9.
11. Scheinfeld N, Lehman DS. An evidence-based review of medical and surgical treatments of genital warts. Dermatol Online J. 2006;12:5.
12. Bard S, Shiman MI, Betty Bellman B, Connelly EA. Treatment of facial molluscum contagiosum with trichloroacetic acid. Pediatr Dermatol. 2009;26:425-6.
13. Sadick N, Sorhaindo L. A comparative split-face study of cryosurgery and trichloroacetic acid 100% peels in the treatment of HIV-associated disseminated facial molluscum contagiosum. Cutis. 2009;83:299-302.
14. Rolewski S. Clinical review: topical retinoids. Dermatol Nurs. 2003;15:447-50.
15. Scheinfeld N. Treatment of molluscum contagiosum: a brief review and discussion of a case successfully treated with adapalene. Dermatol Online J. 2007;13(3):15.
16. Garrett SJ, Robinson JK, Roenigk HH Jr. Trichloroacetic acid peel of molluscum contagiosum in immunocompromised patients. J Dermatol Surg Oncol. 1992;18:855-8.
17. Rajouria EA, Amatya A, Karn D. Comparative Study of 5 % Potassium Hydroxide Solution Versus 0.05% Tretinoin Cream for Molluscum Contagiosum in Children. Kathmandu Univ Med J. 2011;36:291-4.
18. Mahajan B B, Pall A, Gupta R R. Topical 20% KOH-An effective therapeutic modality for moluscum contagiosum in children. Indian J Dermatol Venereol Leprol. 2003;69:175-7.
19. Gupta R. Plantar warts treated with topical adapalene. Indian J Dermatol. 2011;56:513-4.
20. Inayat S, Khurshid K, lnayat M, Pal SS. Comparison of efficacy and tolerability of topical 0.1% adapalene gel with 0.05% isotretinoin gel in the treatment of acne vulgaris. J Pak Assoc Dermatol. 2012;22:240-7.
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