Efficacy of topical 10% potassium hydroxide in the treatment of molluscum contagiosum in children
DOI:
https://doi.org/10.66344/jpad.v32i2.1892Abstract
Objective To assess the efficacy of topical 10% Potassium Hydroxide (KOH) in treatment of molluscum contagiosum in children.
Methods Interventional study of 90 patients meeting inclusion criteria was done from 6th May 2020 to 6th Nov 2020. After written informed consent, patients were advised in detail to start topical 10% potassium hydroxide application till appearance of signs of inflammation i.e., redness and followed up in outdoor to assess for complete disappearance of lesions at 2 months. Patients’ demographic details, duration of disease at presentation and complete disappearance at 2 months were recorded in the proforma.
Results Mean age of the patients was 3.92±1.60 years (range2 to 6 years). 58.9% patients were male and 41.1% were female. Majority (44.4%) of patients presented with in 10-20 days of appearance of disease. Complete disappearance of disease was noted in 92.2% patients at 2 months of treatment.
Conclusion Topical 10% potassium hydroxide is an effective treatment of molluscum contagiosum.
References
1. Sterling JC. Virus Infections. . In: Burns T, Breathnach S, Cox N, Griffith C. Rook’s Textbook of Dermatology, 8th ed. West Sussex: Willey Blackwell; 2010. P. 33.11-2.
2. Rajouria EA, Amatya A, Karn D. Comparative study of 5% Potassium Hydroxide solution versus 0.05% Tretinoin cream for Molluscum Contagiosum in children. Kathmandu Univ Med J. 2011;36: 291-4.
3. Jessica H, Wynnis T. Separating Fact from Fiction in Molluscum Contagiosum. Pract Dermatol Pediat. 2010;1:34-7.
4. Marsal JR, Cruz I, Teixido C, Diez O, Martinez M, Galindo G et al. Efficacy and tolerance of the topical application of Potassium Hydroxide (10% and 15%) in the treatment of Molluscum Contagiosum: Randomized clinical trial: Research protocol. BMJ Infect Dis. 2011;11:278.
5. Thappa MD. Clinical pediatric dermatology. Noida, India: Elsevier, A division of Reed Elsevier India Pvt. Ltd; 2009. p. 50.
6. Smith KJ, Yeager J, Usn MC, Skelton H. Molluscum contagiosum: It’s clinical, histopathologic, and immunohistochemical spectrum. Int J Dermatol. 1999;38:664-72.
7. Metkar A, Pande S, Khopkar U. An open, nonrandomized, comparative study of Imiquimod 5% cream versus 10% potassium hydroxide solution in treatment of molluscum contagiosum. Indian J Dermatol Venerol Leprol. 2008;74:614-8.
8. Short KA, Fuller LC, Higgins EM. Double-blind, Randomized, Placebo-controlled trial of the use of topical 10% Potassium Hydroxide solution in the treatment of Molluscum Contagiosum. Pediatr Dermatol. 2006;23:279-81.
9. Seo SH, Chin HW, Jeong DW, Sung HW. An open, Randomized comparative clinical and histological study of Imiquimod 5% cream versus 10% Potassium Hydroxide solution in the treatment of Molluscum Contagiosum. Ann Dermatol. 2010;22:156-62.
10. Mahajan BB, Pall A, Gupta RR. Topical 20% Potassium Hydroxide- an effective therapeutic modality for Molluscum Contagiosum in children. Indian J Dermatol Venereol Leprol. 2003;69:175-77.
11. Muzaffar F, Faiz F. Comparison of 5% potassium hydroxide with 10% potassium hydroxide solution in treatment of molluscum contagiosum: A comparative study. J Pak Assoc Dermatol. 2014;24(4): 337-41.
12. Romiti R, Ribeiro AP, Grinblat BM, Rivitti EA, Romiti N. Treatment of molluscum contagiosum with potassium hydroxide: a clinical approach in 35 children. Pediatr Dermatol. 1999;16(3):228-31.
13. Muzaffar, Farhana. 10% Potassium hydroxide solution vs. cryotherapy in the treatment of molluscum contagiosum: A case-control study. J Pak Assoc Dermatol. 2011;21(3):185-9.
14. Al-Hamdi KI, AL-Rahmani MAA. Evaluation of Topical Potassium Hydroxide Solution for Treatment of Plane Warts. Indian J Dermatol Venerol Leprol. 2012;57(1):38-41.
15. Handjani F, Behazin E, Sadati MS. Comparison of 10% potassium hydroxide solution versus cryotherapy in the treatment of molluscum contagiosum: An open randomized clinical trial. J Dermatolog Treat. 2014;25(3):249-50.
16. Can B, Topaloğlu F, Kavala M, Turkoglu Z, Zindancı I, Sudogan S. Treatment of pediatric molluscum contagiosum with 10% potassium hydroxide solution. J Dermatolog Treat. 2014;25(3):246-8.
17. Laxmisha C, Thappa DM, Jaisankar TJ. Clinical profile of molluscum contagiosum in children versus adults. Dermatol Online J. 2003;9(5):1.
18. Dohil MA, Lin P, Lee J, Lucky AW, paller AS, Eichenfield LF. The epidemiology of molluscum contagiosum in children. J Am Acad Dermatol. 2006;54(1):47-54.
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