Subcutaneous spindle cell/ pleomorphic lipoma: A case report of a peculiar tumor entity
DOI:
https://doi.org/10.66344/jpad.v31i4.1787Abstract
Spindle cell/ pleomorphic lipoma (SCL/PL) is a rare histologic subtype of lipoma. It occurs in a characteristic clinical settings, arising mainly in middle-aged and older men in subcutaneous tissue of the posterior neck, upper back, and shoulders (shawl region). In women, it much more comonly develops outside the typical shawl location. The author describes a 66-year-old man with a subcutaneous tumor mass in the left back side of the neck. It consisted of bland spindle cell population situated in a fibromyxoid stroma containing thick collagen bundles. Scattered pleomorphic and multinucleated floret-like giant cells were also found. The neoplastic cells showed CD34-positive/S100-negative immunophenotype. A diagnosis of a SCL/PL was established. Subcutaneous SCL/PL is an unfamiliar tumor entity to most dermatologists. Despite the worrisome name it is a clearly benign lesion with no tendency to recur after surgical treatment. The present paper is excellent for demonstrating its unique clinical and histomorphological characteristics.
References
1. Sajad Ahmad Salati. Palmar lipoma: A case report. J Pak Assoc Dermatol.2018;4:540-3.
2. WHO Classification of Tumours Editorial Board. Soft tissue and bone tumours. 5th Ed.; vol. 3, Lyon: IARC; 2020. ISBN 978-92-832-4502-5
3. Linberg MR. Diagnostic Pathology. Soft Tissue Tumors. Third Edition, Elsevier 2019. ISBN 978-0-323-66110-2
4. Enzinger FM, Harvey DA. Spindle cell lipoma. Cancer. 1975; 36:1852-1859.
5. Shmookler BM, Enzinger FM. Pleomorphic lipoma: a benign tumor simulating liposarcoma. A clinicopathological analysis of 48 cases. Cancer.1981;47:126-33.
6. Van Treeck BJ, Fritchie KJ. Updates in spindle cell/pleomorphic lipomas. Semin Diagn Pathol.2019;36:105-11.
7. Ko JS, Daniels B, Emanuel PO, et al. Spindle cell lipoma in women: A report of 53 cases. Am J Surg Pathol.2017;41:1267-74.
8. Syed S, Martin AM, Haupt H, et al. Frequent detection of androgen receptors in spindle cell lipomas: an explanation for this lesion's male predominance ? Arch Pathol Lab Med.2008;132:81-3.
9. Chen S, Huang H, He S, et al. Spindle cell lipoma: clinicopathologic characterization of 40 cases. Int J Clin Pathol.2019;12:2613-21.
10. Ud Din N, Zhang P, Sukov WR, et al. Spindle cell lipomas arising in atypical locations. Am J Clin Pathol.2016;146:487-95.
11. Veselý K. Myxoid tumors of soft tissues. Cesk Patol.2017;53:71-80.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Vladimír Bartoš
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.
