Treatment of Multiple Cutaneous Leishmaniasis Lesions in Diabetic Patient with Photodynamic Therapy
Treatment of Multiple CL Lesions in Diabetic Patient with PDT
DOI:
https://doi.org/10.66344/jpad.v31i4.1755Abstract
Cutaneous leishmaniasis (CL) is the most common type of leishmaniasis. It is originated by different species of the protozoan parasite leishmania, transmitted by infected female sand flies. Although CL is not life-threatening, still may leave quite disfiguring and ugly scars on infected areas. In this case report, we detail the case of a sixty-five-year-old diabetic male patient with CL, associated with multiple chronic disfiguring ulcers on foot, ear, leg and arm. The patient was successfully treated with methyl amino levulinate based photodynamic therapy (PDT) and after 5 sessions, complete response was achieved. The patient was followed with excellent cosmetic outcome, with no recurrence throughout the observation time and no complication was observed. This study demonstrates the promising role of PDT in the treatment of CL. We have formulated photosensitizer through our institute developed protocol, which increase its efficacy and bring down the medicine cost from US$ 500 to US$ 50.
References
1. Alemayehu, B. and M. Alemayehu, Leishmaniasis: a review on parasite, vector and reservoir host. Health Sci J.2017;11(4): 1.
2. Meinecke, C.K., et al., Congenital transmission of visceral leishmaniasis (Kala Azar) from an asymptomatic mother to her child. Pediatrics.1999;104(5):e65.
3. Cruz, I., et al., Leishmania in discarded syringes from intravenous drug users. The Lancet.2002;359(9312):1124-5.
4. Ready, P.D., Biology of phlebotomine sand flies as vectors of disease agents. Annu Rev Entomol.2013.58.
5. Durrani, A.Z., et al., Prevalence of cutaneous leishmaniasis in humans and dogs in Pakistan. Pak J Zoo.2011.43(2).
6. Organization, W.H., Investing to overcome the global impact of neglected tropical diseases: third WHO report on neglected tropical diseases 2015. Vol. 3. 2015: World Health Organization.
7. Kim, M., H.Y. Jung, and H.J. Park, Topical PDT in the treatment of benign skin diseases: principles and new applications. Int J Mol Sci.2015;16(10):23259-78.
8. Gardlo, K., et al., Treatment of cutaneous leishmaniasis by photodynamic therapy. J Am Acad Dermatol.2003;48(6):893-6.
9. MacCormack, M.A. Photodynamic therapy in dermatology: an update on applications and outcomes. in Seminars in cutaneous medicine and surgery. 2008. WB Saunders.
10. Van Straten, D., et al., Oncologic photodynamic therapy: basic principles, current clinical status and future directions. Cancers.2017;9(2):19.
11. Durrani, A.Z., H.Z. Durrani, and N. Kamal, Prevalence of Leishmania in sand fly in Pakistan. Pak J Zoo.2012.44(1).
12. Thakur, C., et al., Rationalisation of regimens of treatment of kala-azar with sodium stibogluconate in India: a randomised study. Br Med J.1988; 296(6636):1557-61.
13. Ghorbani, M. and R. Farhoudi, Leishmaniasis in humans: drug or vaccine therapy? Drug Des Devel Ther.2018;12: 25-40
14. Khan, K., et al., Fractionated illumination improves the treatment outcomes of photodynamic therapy for high grade cutaneous leishmaniasis. Photodiagnosis Photodyn Ther.2020;29:101622.
15. Guerin, P.J., et al., Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infect Dis. 2002;2(8):494-501.
16. Khan, A., G. Biradar, and M. Khan, Treatment of cutaneous leishmaniasis with photodynamic therapy: The first case report from Khyber Pakhthunkhwa (KPK), Swat Pakistan. J Pak Assoc Dermatol.2021; 31(1):120-4.
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Aakifullah Khan, Ghufran Biradar, Karim Khan, Moiz Khan, Javaid Ali
This work is licensed under a Creative Commons Attribution 4.0 International License.
Submission declaration
Authors retain the copyright to their work and grant the 'Journal of Pakistan Association of Dermatologists (JPAD)' the right of first publication under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. This license allows others to share, adapt, and reuse the work for any purpose, including commercial use, as long as appropriate credit is given to the original authors and the journal.
By submitting a manuscript, authors confirm that the work has not been published previously (except as an abstract, lecture, or academic thesis), is not under review elsewhere, and has been approved by all authors and relevant authorities. Once accepted, the article will be openly accessible under the CC BY 4.0 license, ensuring wide dissemination and reuse with proper attribution.
