Frequency of dyslipidemia in patients with lichen planus
DOI:
https://doi.org/10.66344/jpad.v31i4.1717Abstract
Background Lichen planus is a chronic T-cell-mediated inflammatory disorder, where inflammation produces lipid metabolism disturbances and is therefore linked to increase in cardiovascular (CV) risk due to dyslipidemia. Increased reactive oxygen species and lipid peroxides have also been implicated in its pathogenesis.
Objective To determine the frequency of dyslipidemia in patients with lichen planus.
Methods In this cross sectional study 96 clinically diagnosed cases of lichen planus were included. Presence or absence of dyslipidemia was decided by the recorded parameters i.e. fasting lipid profile.
Results Mean age of the patients was 37.07±11.22 year. There were 47 males (49.0%) and 49 females (51.0%). Dyslipidemia was recorded in 38 patients (39.6%). Stratification with regard to age, gender, BMI, duration of disease and history of treatment was carried out.
Conclusion Lichen planus was significantly associated with an increased risk of dyslipidemia.
References
1. Le Cleach L, Chosidow O. Lichen planus. N Engl J Med.2012;366(8):723–32.
2. Dreiher J, Shapiro J, Cohen AD. Lichen planus and dyslipidaemia: a case-control study. Br J Dermatol.2009;161:626–9.
3. Arias-Santiago S, Eisman AB, Fernandez JA, Grion-prieto MS. Mellado VG, Naranjo-sintes R. Cardiovascular risk factors in patients with lichen planus. Am J Med. 2011;124(6):543-8.
4. Saleh N, Samir N, Megahed H, Farid E. Homocysteine and other cardiovascular risk factors in patients with lichen planus. J Eur Acad Dermatol Venereol. 2014; 28(11):1507-13.
5. Diagnosis and Management of metabolic syndrome-an American Heart Association scientific statement. [online]. 2005 [cited 2015 Aug 30]; Available from :URL; http://circ.ahajournals.org/content/109/3/433/T2.expansion.html/
6. Sezer E, Ozugurlu F, Ozyurt H. Lipid peroxidation and antioxidant status in lichen planus. Clin Exp Dermatol.2007;32:430-4.
7. Lian Y, Xie L, Liu Y, Tang F. Metabolic-related markers and inflammatory factors as predictors of dyslipidemia among urban Han Chinese adults. Lipids Health Dis. 2019;18(1):167.
8. Krishnamoorthy B, Suma GN , Mamatha N S, Sowbhagya M B, Garlapati K. Lipid profile and metabolic syndrome status in patients with oral lichen planus,oral lichenoid reaction and healthy individuals. J Clin Diagn Res.2014;8(11):92-5.
9. Baykal L, Arıca DA, Yaylı S, Örem A, Bahadır S, Altun E, et al. Prevalence of metabolic syndrome in patients with mucosal lichen planus: A case-control study. Am J Clin Dermatol.2015;16(5):439-45.
10. Lowe NJ, Cudworth AG, Clough SA, Bullen MF. Carbohydrate metabolism in lichen planus. Br J Dermatol.1976;95:9-13.
11. Romero MA, Seoane J, Varela-Centelles P, Diz Dios P, Garcı’a Pola M. Prevalence of diabetes mellitus amongst oral lichen planus patients Clinical and pathological characteristics. Med Oral.2002;7:121–9.
12. Gisondi P, Fostini AC, Fossà I, Girolomoni G, Targher G. Psoriasis and the metabolic syndrome. Clin Dermatol.2018;36(1):21–8.
13. Lai YC, Yew YW, Schwartz RA. Lichen planus and dyslipidemia: a systematic review and meta-analysis of observational studies. Int J Dermatol. 2016;55(5):e295-304.
14. Kuntoji V, Kudligi C, Bhagwat PV, Manasa DR, Sharma A, Andanappanavar V, et al. Dyslipidemia and metabolic syndrome in patients with lichen planus: A case-control study. J Pak Assoc Dermatol. 2016;26(4):290–7.
15. Khan S, Pirzado MS, Kalhoro HBA, Rajper N, Memon SM, Memon FH. Frequency of dyslipidemia in patients with lichen planus: A comparative cross-sectional study. Available from:
https://www.lumhs.edu.pk/jlumhs/Online-First/May0821.pdf
16. Özkur E, Uğurer E, Altunay İK. Dyslipidemia in lichen planus: A case-control study. Sisli Etfal Hastan Tip Bul.2020;54(1):62-6.
17. Conic RRZ, Piliang M, Bergfeld W, Atanaskova-Mesinkovska N. Association of Lichen Planopilaris With Dyslipidemia. JAMA Dermatol.2018;154(9):1088–9.
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Copyright (c) 2022 Zunaira Arshad, Wajeeha Nusrat, Madiha Sanai, Maheneema Asghar, Aisha Ghias, Atiya Arshad, Shahbaz Amaan
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