A Chinese patient with multiple primary melanomas
DOI:
https://doi.org/10.66344/jpad.v31i3.1651Keywords:
Melanoma, Mutation, Multiple Primary Melanoma, PET CT, Skin CancerAbstract
Melanoma is a highly malignant skin tumor with an increasing incidence in Asian Population. We had a Chinese man with multiple primary melanomas on the chest and head region. The lesions were having irregular boundaries, with variable depth, and the patient was free of systemic symptoms. The diagnosis was confirmed by the immune-histopathological examination. Lesions were surgically removed. Risk factors include age, white race, sun-exposed parts, family history, and multiple nevis
References
1. Puntervoll HE, Yang XR, Vetti HH, et al. Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants. J Med Genet.2013;50:264-70.
2. Goldstein AM, Chan M, Harland M, et al. Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents. J Med Genet.2007;44:99-106.
3. Bertolotto C, Lesueur F, Giuliano S, et al. ASUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. Nature.2011;480:94-8.
4. Siegel R, Ma J, Zou Z, et al. Cancer Statistics, 2014. CA Cancer J Clin. 2014;64:9-29.
5. Jemal A, Murray T, Ward E, et al. Cancer Statistics, 2005. CA Cancer J Clin 2005;55:10-30.
6. Ferrone CR, Ben Porat L, Panageas KS, et al. Clinicopathological features of and risk factors for multiple primary melanomas. JAMA.2005;294:1647-54.
7. Van der Leest RJ, Liu L, Coebergh JW, et al. Risk of the second primary in situ and invasive melanoma in a Dutch population-based cohort: 1989-2008. Br J Dermatol. 2012;167:1321-30.
8. Vecchiato A, Pasquali S, Menin C, et al. Histopathological characteristics of subsequent melanomas in patients with multiple primary melanomas. J Eur Acad Dermatol Venereol.2014;28:58-64.
9. Siskind V, Hughes MC, Palmer JM, et al. Nevi, family history, and fair skin increase the risk of second primary melanoma. J Invest Dermatol.2011;131:461-7.
10. Moore MM, Geller AC, Warton EM, et al. Multiple primary melanomas among 16570 patients with melanoma diagnosed at Kaiser Permanente Northern California, 1996 to 2011. J Am Acad Dermatol.2015;73:630-6.
11. Youlden DR, Baade PD, Soyer HP, et al. Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study. J Invest Dermatol.2016;136:2270-6.
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Copyright (c) 2021 Jianning SUN, qazi syed irfanullah shah, Farhan Younas, Xuefeng Wan
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