Pacinian neurofibroma: A rare case report

Authors

  • Dr. Kardiana
  • Dr. Muslimin

DOI:

https://doi.org/10.66344/jpad.25.4.2015.160

Keywords:

Pacinian neurofibroma, Pacinian bodies, S-100 antibodies

Abstract

A 25-year-old, Javanese, Indonesian, female presented with large bumps on the buttocks, hip, and lower abdomen for last 15 years. Local examination revealed multiple, soft, sagging tumor masses that seemed hanging, fused, hyperpigmented, with varying sizes, from the smallest diameter about 1 cm to the largest of 40 cm x 30 cm on the right buttock, 35 cm x 30 cm on the left buttock where both spread up to the hips and lower abdomen, with sharp demarcation, wrinkling and loosening of the surface of the skin. Routine investigations were normal. Histopathology revealed proliferation of fibrous connective tissue accompanied with whorled structures Pacinian bodies that showed no sign of malignancy. Immunohistochemistry examination with antibodies against protein S-100 showed tumor cells with positive immunoreactivity. A diagnosis of Pacinian neurofibroma was made.

References

Huang LL, Wu MT, Lee TL. Pacinian neurofibroma of the scalp. http://www.dermatolsinica. com/web/data/650.pdf (accessed 14 February 2012).

Nath AK, Timshina DK, Thappa DM, Basu D. Pacinian neurofibroma: a rare neurogenic tumor. Indian J Dermatol Venereol Leprol. 2011;7:204-5.

White LE, Levy RM, Alam M. Neoplasias and hyperplasias of muscular and neural origin. In: Wolff K, Goldsmith LA, Katz SI, et al., editors. Fitzpatrick’s Dermatology in General Medicine. Vol 1. 7th ed. New York: McGraw-Hill; 2008. P. 1177-80.

Al-Buainain H, Pal K, El Shafie H et al. Myxoid neurothekeoma: a rare soft tissue tumor of hand in a 5-month-old infant. Int J Dermatol. 2009;54:59-61.

Pernick N. soft tissue tumor. part 3 – Muscle, Vascular, Nerve, Other. 31 October 2009. Available from [on line]: PathologyOutlines.com,Inc.

De Kaminsky AR, Glikin I, Torres Cortijo A et al. Vater Paccini's neurofibroma. Report of 3 cases. Med Cutan Ibero Lat Am. 1989;17:317-20.

MacLennan SE, Melin-Aldana M, Yakuboff KP. Pacinian neurofibroma of the hand : A case report and literature review. J Hand Surg. 1999;24:413-6.

NIH Consens Statement Online. Neurofibromatosis. [on-line]. 1987 Jul 13-15 [dikutip 2009 Des11]; Available from URL. http://consensus.nih.gov/1987/1987Neurofib romatosis064html.htm

Listernick R, Charrow J. The neurofibromatoses. In: Wolff K, Goldsmith LA et al., editors. Fitzpatrick’s Dermatology in General Medicine. Vol 1. 7th ed. New York: McGraw-Hill; 2008. 1331-9.

McCormack K, Kaplan D, Murray JC, Fetter BF. Multiple hairy pacinian neurofibromas (nerve-sheath myxomas). J Am Acad Dermatol. 1988;18:416-9.

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Published

2016-11-26

How to Cite

1.
Kardiana D, Muslimin D. Pacinian neurofibroma: A rare case report. J Pak Assoc Dermatol [Internet]. 2016Nov.26 [cited 2026Apr.12];25(4):337-40. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/160

Issue

Vol. 25 No. 4 (2015): October - December

Section

Case Reports

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